Effects of Phosphodiesterase Inhibitors After Coronary Artery Bypass Grafting
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概要
- 論文の詳細を見る
The aim of this study was to estimate the postoperative effects of phosphodiesterase(PDE) inhibitors(milrinone and olprinone)after coronary artery bypass grafting(CABG). To prevent hypotension caused by the PDE inhibitors, low dose of catecholamines were used concomitantly. A total of 34 elective CABG cases were tested. In 12 cases, 0.25μg kg^<-1> min^<-1> of milrinone, 3μg kg^<-1> min^<-1> of dobutamine(DOB) and dopamine(DOA) were used concomitantly(Group-M). In another 10 patients, 0.1μg kg^<-1> min^<-1> of olprinone and the same doses of the catecholamines were infused(Group-O). As a control, the same doses of DOA and DOB only were administered in 12 patients(Group-C). When the pump flow of the cardiopulmonary bypass(CPB) decreased to half, these drugs were given in all groups. Hemodynamics were recorded before CPB, just after the operation, and 3, 6, 12, 24, 48 and 72h after the operation. Both milrinone and olprinone increased the cardiac index and decreased systemic vascular resistance to almost the same degree. Olprinone decreased mean aortic and pulmonary artery pressures, and also significantly reduced the preload of both right and left heart compared with milrinone. Significant hypotension was not detected due to the concomitant usage of low-dose catecholamines. This concomitant usage of PDE inhibitors and catecholamines allowed easy weaning from CPB, demonstrating excellent hemodynamics after CABG. Good oxygen demand and supply balance were maintained in peripheral tissue. These results suggest that these new PDE inhibitors may be effective not only for weaning from CPB but also for post-cardiotomy cardiogenic shock.
- 社団法人日本循環器学会の論文
- 1999-01-20
著者
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Tsukamoto Saeki
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Hta Hiroaki
Second Department Of Surgery Nihon University School Of Medicine
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Kimura Shunichi
The 2nd Department Of Surgery Nihon University School Of Medicine
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YAGI Shinya
Second Department of Surgery, Nihon University School of Medicine
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Orime Yukihiko
The Second Department of Surgery, Nihon University School of Medicine
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Shiono Motomi
The Second Department of Surgery, Nihon University School of Medicine
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Hata Hiroaki
The Second Department of Surgery, Nihon University School of Medicine
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Yagi Shinya
The Second Department of Surgery, Nihon University School of Medicine
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Tsukamoto Saeki
The Second Department of Surgery, Nihon University School of Medicine
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Okumura Haruhiko
The Second Department of Surgery, Nihon University School of Medicine
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Kimura Shun-ichi
The Second Department of Surgery, Nihon University School of Medicine
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Hata Mitsumasa
The Second Department of Surgery, Nihon University School of Medicine
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Sezai Akira
The Second Department of Surgery, Nihon University School of Medicine
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Obana Masahiro
The Second Department of Surgery, Nihon University School of Medicine
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Sezai Yukiyasu
The Second Department of Surgery, Nihon University School of Medicine
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Hata Mitsumasa
The Department Of Cardiac Surgery Austin & Repatriation Medical Centre University Of Melbourne
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Obana Masahiro
Department Of Cardiovascular Surgery National Hospital Tokyo Disaster Medical Center
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Yagi Shinya
The 2nd Department Of Surgery Nihon University School Of Medicine
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Orime Yukihiko
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Sezai Akira
The Second Department Of Surgery Nihon University School Of Medicine
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Sezai Yukiyasu
The Chairman Of The Board Japanese Association For Coronary Artery Surgery The Former President Of N
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Sezai Yukiyasu
The 2nd. Department Of Surgery Nihon University
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Okumura Haruhiko
Second Department Of Surgery Nihon University School Of Medicine
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