Low-dose Atrial Natriuretic Peptide for Chronic Kidney Disease in Coronary Surgery

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概要

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• Purpose: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease. We investigated the effectiveness of human atrial natriuretic peptide (hANP) infusion in CKD patients undergoing coronary artery bypass grafting (CABG).Patients and Methods: We analyzed 134 consecutive cases in which CABG had been performed in our hospital from 2002 to 2005. They were divided into four groups: Group A (n = 19) was CKD + placebo, Group B (n = 30) was non-CKD + placebo, Group C (n = 22) was CKD + hANP, and Group D (n = 63) was non-CKD + hANP). The serum creatinine (mg/dl) and estimated glomerular filtration rate (ml/min/1.73 m2) were measured as evaluation values.Results: The value of sCr changed preoperatively and at 1 year postoperatively from 1.09 ± 0.09, 51.3 ± 4.4 to 1.26±0.42, 49.4±14.4 in Group A, from 0.77 ± 0.14, 75.5 ± 12.1 to 0.91 ± 0.40, 72.3 ± 19.5 in Group B, from 0.99 ± 0.12, 54.8 ± 3.0 to 0.93 ± 0.16, 64.2 ± 12.3 in Group C and from 0.77 ± 0.13, 77.7 ± 13.4to 0.83 ± 0.17, 75.9 ± 16.2 in Group D, respectively. There was a significant difference between Group A and Group C regarding the change of creatinine (p =0.0022)Conclusion: Our study has confirmed that an infusion of hANP during CABG in patients with CKD not only improves perioperative renal function, but also prevents the progression of CKD.

• 2011-08-01

著者

• Sezai Akira

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• SHIONO Motomi

  Department of Cardiovascular Surgery, Nihon University School of medicine

• Wakui Sinji

  From Department Of Thoracic And Cardiovascular Surgery Nihon University Hospital

• Hata Mitsumasa

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• Hata Mitsumasa

  The Department Of Cardiac Surgery Austin & Repatriation Medical Centre University Of Melbourne

• YOSHITAKE ISAMU

  Department of Cardiovascular Surgery, Nihon University School of Medicine

• Yoshitake Isamu

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• Shiono Motomi

  Division Of Cardiovascular Surgery Department Of Surgery Nihon University Scool Of Medicine

• Unosawa Satoshi

  Department Of Cardiovascular Surgery Nihon University Nerimahikarigaoka Hospital

• Hata Mitsumasa

  Department Of Cardiac Surgery Austin & Repatriation Medical Centre University Of Melbourne

• Wakui Shinji

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• Shiono Motomi

  Department Of Cardiovascular Surgery Nihon University School Of Medicine

• Shiono Motomi

  The 2nd. Department Of Surgery Nihon University

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