Prospective Randomized Trial for Optimal Prophylactic Treatment of the Upper Gastrointestinal Complications After Open Heart Surgery

概要

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Background Upper gastrointestinal bleeding is a lethal complication after open heart surgery. We designed a prospective randomized trial to test the efficacy of different antisecretory agents to prevent upper gastrointestinal disease after operation. Methods and Results A total of 210 patients were divided into 3 groups : group I had 70 patients who had mucosal protection (teprenone 150mg/day), group II had 70 patients who had histamine 2-receptor antagonist (ranitidine 300mg/day), and group III included 70 patients who had a proton pump inhibitor (rabeprazole 10mg/day). Gastric fiberscopy was used in all patients postoperatively during days 5 to 7. We compared the 3 groups in terms of endoscopic findings. Four patients (5.7%) had gastric bleeding complications in each of groups I and II ; 2 died of coagulopathy. In group III no patients had gastric bleeding. The incidence of hemorrhagic gastritis was significantly higher in groups I (22.9%) and II (15.7%) than in III (2.9%) (p=0.0003). The incidence of active ulcers was also significantly higher in groups I (28.6%) and II (21.4%) than in III (4.3%) (p=0.0001). Conclusions Early medication postoperative by a proton pump inhibitor was shown to be the most effective treatment and indeed might be described as mandatory to prevent upper gastrointestinal diseases after open heart surgery.
2005-02-20