Effects of Olmesartan on the Renin-angiotensin-aldosterone System for Patients with Essential Hypertension after Cardiac Surgery : Investigation Using a Candesartan Change-over Study
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概要
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Background: Various angiotensin II receptor blockers are widely used for the treatment of hypertension in recent years. The results of large-scale clinical studies have shown that they have various efficacies: not only hypotensive effects but also organ protective effects. In this study, the effects of a change-over from candesartan to olmesartan on renin-angiotensin-aldsterone system, cardiomegaly and peripheral circulation were studied.Methods: Participants enrolled in this trial were outpatients with essential hypertension after cardiac surgery who had received candesartan for more than one year. Fifty-six patients switched from candesartan to olmesartan. The primary endpoints were 1) renin activity, angiotensin II, aldosterone, and 2) left ventricular mass index (LVMI).Results: It was clear that angiotensin II and aldosterone are decreased by the potent hypotensive effects of olmesartan in a change-over from candesartan to olmesartan. Since LVMI and BNP were decreased, inhibitory effects on myocardial hypertrophy were also confirmed.Conclusion: In the present study, left ventricular hypertrophy and on arterial compliance were inhibited by a decrease in angiotensin II and aldosterone due to the change-over to olmesartan. In the future, protective effects on organs will be clarified by long-term observations.
- 2011-10-01
著者
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Sezai Akira
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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SHIONO Motomi
Department of Cardiovascular Surgery, Nihon University School of medicine
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Wakui Sinji
From Department Of Thoracic And Cardiovascular Surgery Nihon University Hospital
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Hata Mitsumasa
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Hata Mitsumasa
The Department Of Cardiac Surgery Austin & Repatriation Medical Centre University Of Melbourne
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YOSHITAKE ISAMU
Department of Cardiovascular Surgery, Nihon University School of Medicine
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Yoshitake Isamu
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Shiono Motomi
Division Of Cardiovascular Surgery Department Of Surgery Nihon University Scool Of Medicine
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Unosawa Satoshi
Department Of Cardiovascular Surgery Nihon University Nerimahikarigaoka Hospital
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Soma Masayoshi
Department Of Endocrinology Nihon University School Of Medicine
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Hata Mitsumasa
Department Of Cardiac Surgery Austin & Repatriation Medical Centre University Of Melbourne
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Wakui Shinji
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Shiono Motomi
Department Of Cardiovascular Surgery Nihon University School Of Medicine
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Shiono Motomi
The 2nd. Department Of Surgery Nihon University
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