Effects of Various Doses of Intracoronary Diltiazem on Coronary Resistance Vessels in Humans
スポンサーリンク
概要
- 論文の詳細を見る
We investigated the vasodilative effects of various doses of intracoronary diltiazem on coronary resistance vessels. Nine patients with normal angiograms were studied. A coronary Doppler guide wire was inserted into the left anterior descending coronary artery. Diltiazem, in doses of 0.1 mg, 0.5 mg, 1.0 mg, 2.0 mg and 4.0 mg, was injected into the left coronary artery at 10 min intervals and coronary blood flow velocity was measured. The coronary artery was pretreated with intracoronary nitroglycerin to avoid changes in the cross-sectional area. As a measure of the change in coronary vascular resistance, a coronary vascular resistance index (CVRI) was calculated as mean aortic pressure/coronary blood flow velocity. An injection of diltiazem into the left coronary artery caused a significant dose-dependent decrease in CVRI. A dose of 2.0 mg was the lowest dose on the plateau of the dose-response curve. In conclusion, the injection of diltiazem into the left coronary artery causes a dose-dependent dilatation of coronary resistance vessels, and the maximal effect can be produced with a dose of 2.0 mg.
- 社団法人日本循環器学会の論文
- 1995-11-20
著者
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KURISU Satoshi
Department of Cardiology, Hiroshima City Hospital
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KAWAGOE Takuji
Department of Cardiology, Hiroshima City Hospital
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ISHIHARA Masaharu
Department of Cardiology, Hiroshima City Hospital
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SHIMATANI Yuji
Department of Cardiology, Hiroshima City Hospital
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Ishihara Masaharu
Department Of Cardiology Hiroshima City Hospital
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UEDA Atsushi
Department of Physical Science, Hiroshima University
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Sato H
順天堂大学 循環器内科
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Hondo Tatsuya
First Department Of Internal Medicine Hiroshima University School Of Medicine
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Satou Hikaru
Hiroshima City Hospital
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Kawagoe Takuji
Department Of Cardiology Hiroshima City Hospital
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Shimatani Yuji
Department Of Cardiology Hiroshima City Hospital
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Kurisu Satoshi
Department Of Cardiology Hiroshima City Hospital
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Sato Hikaru
Department of Cardiology, Hiroshima City Hospital
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Tateishi Hironobu
Department of Cardiology, Hiroshima City Hospital
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Sato Hikaru
Division Of Cardiology Hiroshima City Hospital
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Ueda Atsushi
Department Of Community Health Nursing School Of Health Sciences Kumamoto University
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Sato Hikaru
Dept.of Cardiology Hiroshima City Hospital
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Tateishi Hironobu
Department Of Cardiology Hiroshima City Hospital
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Tateishi Hironobu
Department Of Internal Medicine Hiroshima City Hospital
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Ueda Atsushi
Department Of Cardiology Hiroshima City Hospital
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SATO Hikaru
Department of Applied Biological Chemistry, Faculty of Agriculture, Shizuoka University
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