Lymphocyte Subsets in Patients with Acute Myopericarditis, Arrhythmias and Dilated Cardiomyopathy : SYMPOSIUM ON SEVERAL ASPECTS OF MYOCARDITIS
スポンサーリンク
概要
- 論文の詳細を見る
To investigate the role of immunoregulatory function in determining the clinical course of acute myopericarditis, lymphocyte subsets were analysed by laser flow cytometry in 20 patients with acute myopericarditis, 30 with various arrhythmias or atrio-ventricular block and 31 with dilated cardiomyopathy. During the healing stage of acute myopericarditis, patients with residual electrocardiographic or left ventricular wall motion abnormalities presented altered frequencies of lymphocyte subsets, increased B 1 and reduced OKT 8 positive cells with an elevated OKT 4/8 ratio. The abnormal pattern was not evident in patients with acute pericarditis nor in those with acute myocarditis who recovered completely without residual abnormalities. This observation suggests that an imbalance of helper/suppressor T cells could modulate the clinical course of acute myopericarditis, wither by producing extensive and irreversible myocardial damage during acute illness or by inducing chronic smoulding myocardial inflammation. Patients with ventricular arrhthmias and left ventricular wall motion abnormalities also presented reduced suppressor/cytotoxic T cells, implying that they had bee suffering from chronic smoulding myocarditis mediated by immunoregulatory dysfunction. However, we could not mediate the progression from myocarditis to dilated cardiomyopathy, since no association was demonstrated between the abnormal lymphocyte subsets and mononuclear cell infiltration in endomyocardial biopsy sample from patients with dilated cardiomyopathy.
- 社団法人日本循環器学会の論文
- 1989-01-20
著者
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Miyazaki Yoshitaka
The Third Department Of Internal Medicine
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Toshima Hironori
The Third Department Of Medicine Kurume University School Of Medicine
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Koga Yoshinori
The Institute of Cardiovascular Diseases, Kurume Univ., Kurume, Japan
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Koga Yoshinori
The Institute Of Cardiovascular Disease Kuruue University Schcool Of Medicine
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Koga Yoshinori
Institute Of Cardiovascular Diseases Kurume Univ. School Of Med.
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TAKAMOTO TETSURO
The Department of Immunology, Kurume University School of Medicine
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YOKOYAMA MITCHEL
The Department of Immunology, Kurume University School of Medicine
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HORI YOSHIHARU
The Department of Immunology Kurume University School of Medicine
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Yokoyama M.mitsuo
The Department Of Immunology Kurume University School Of Medicine
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Koga Yoshinori
Institute Of Cardiovascular Disease
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Toshima Hironori
The 3rd Dept. Of Int. Med. Kurume Univ. School Of Med.
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Koga Yosinori
3rd Department Of Internal Medicine Kurume University School Of Medicine
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Toshima Hironori
The Third Departmelet Of Internal Medicine Kurume University Medical School Kurume
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Takamoto Tetsuro
The Department Of Immunology Kurume University School Of Medicine
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Toschima Hironori
1st Medical Clinic Kyushu University
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Toshima Hironori
The 3rd Department Of Lnternal Medicine Kurume University Medical School
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