A PROTEASE INHIBITOR, NCO-700, IMPROVES THE CONTRACTILE FUNCTION IN STUNNED CANINE MYOCARDIUM

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概要

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• To explore the role of calcium-dependent protease in the stunned myocardium, open-chest dogs underwent 15 min of left anterior descending coronary artery occlusion followed by 2 h of reperfusion. Dogs received a single bolus intravenous injection of either the protease inhibitor NCO-700 (n=6) or saline (n=6) 1 min before reperfusion followed by a 30-min infusion at the same dose. Regional myocardial function was assessed in terms of systolic wall thickening with an epicardial Doppler probe. The two groups exhibited comparable systolic thickening under baseline conditions and similar degrees of dyskinesis during occlusion. After reperfusion, recovery of contractile function, expressed as a percentage of the baseline value, was significantly greater in NCO-700-treated dogs as than in control dogs: -14.3±10.6 vs -48.9±7.2 (p<0.05) at 15 min, 10.8±10.3 vs -31.1±9.0 (p<0.05) at 30 min, 42.5±10.1 vs -16.4±9.1 (p< 0.005) at 1 h, and 47.5±8.3 vs -14.9±9.4 (p<0.001) at 2 h. The data suggest that the protease inhibitor markedly improved contractile function in stunned myocardium by inhibiting intracellular protease activity.

• 社団法人日本循環器学会の論文
• 1994-08-20

著者

• Toshima H

  The Third Department Of Medicine Kurume University School Of Medicine

• Ikeda Hisao

  Division Of Cardiology Kurume University Medical Center

• Toshima Hironori

  The Third Department Of Medicine Kurume University School Of Medicine

• TOSHIMA HIRONORI

  Japanese Circulation Society(JCS)Task Force Committee on Chronic Myocarditis

• Toshima Hironori

  Department Of Public Health Nagoya University Graduate School Of Medicine

• Toshima Hironori

  Iii Department Of Medicine Kurume Univ. School Of Medicine

• Nakayama Hiroshi

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Koga Y

  Division Of Cardiovascular Disease Kurume University Medical Center

• Ueno Takafumi

  Department Of Internal Medicine Iii Kurume University School Of Medicine

• Ueno Takafumi

  The 3rd Dept. Of Int Med. Kurume Univ.

• Ueno Takafumi

  Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med

• Koga Yoshinori

  The Thired Department of Internal Medicine, Kurume University, Medical School

• Koga Yoshinori

  Department Of Cardiology Kurume Medical Center Kurume University

• Koga Yoshinori

  Institute Of Cardiovascular Diseases Kurume Univ. School Of Med.

• Ikeda Hisao

  The Third Department of Internal Medicine, Kurume University School of Medicine

• ODA TAMEO

  The Third Department of Internal Medicine, Kurume University School of Medicine

• KUWANO KAZUNORI

  The Third Department of Internal Medicine, Kurume University School of Medicine

• UENO TAKAFUMI

  The Third Department of Internal Medicine, Kurume University School of Medicine

• Toyomasu Hiroyuki

  2nd Surgery Kurume University School Of Medicine

• Ikeda Hisao

  Department Of Internal Medicine Iii Kurume University School Of Medicine

• Koga Yoshinori

  Department Of Medicine Iii Kurume University School Of Medicine

• Oda Tameo

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Toshima Hironori

  The 3rd Dept. Of Int. Med. Kurume Univ. School Of Med.

• Kuwano Kazunori

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Koga Yosinori

  3rd Department Of Internal Medicine Kurume University School Of Medicine

• Toshima Hironori

  The Third Dpt Of Internal Of Medicine Kurume University School Of Medicine

• Takahashi Hiromi

  Third Department Of Internal Medicine Kurume University School Of Medicine

• Toshima Hironori

  The Third Departmelet Of Internal Medicine Kurume University Medical School Kurume

• Ikeda Hisao

  The Third Department Of Internal Medicine Kurume University

• Koga Yoshinori

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Koga Yoshinori

  3rd Department Of Internal Medicine Kurume University School Of Medicine

• Toshima Hironori

  The 3rd Department Of Internal Medicine Kurume University

• Toyomasu Hiroyuki

  The Third Dpt Of Internal Of Medicine Kurume University School Of Medicine

• Takahashi Hiromi

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Toschima Hironori

  1st Medical Clinic Kyushu University

• Koga Yoshinori

  Dept. Of Pediatrics And The Institute Of Cardiovascular Disease Kurume University

• Ueno Takafumi

  Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med

• Toshima Hironori

  The 3rd Department Of Lnternal Medicine Kurume University Medical School

• Toshima Hironori

  The Third Department Of Internal Medicine Kurume University School Of Medicine

• Kuwano Kazunori

  Third Department Of Internal Medicine Kurume University School Of Medicine

• Ueno Takafumi

  Division Of Cardio-vascular Medicine Department Of Internal Medicine Kurume University School Of Med

• Koga Yoshinori

  The Third Department Of Internal Medecine Kurume University School Of Medicine

• Toshina Hironori

  3rd Dept. Of Intern. Med. Kurume Univ. School Of Med

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