Dilated Cardiomyopathy : Clinical Significance of Possible Related Factors : SYMPOSIUM ON CURRENT STATUS OF DILATED CARDIOMYOPATHY : 50th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
The present study investigates the clinical significance of several possible causative or conditioning factors which have been proposed to be involved in the pathogenesis of dilated cardiomyopathy (DCM). By reviewing the medical records of 68 patients with DCM, we found a definite, and suggestive family history in 16%, and 28%, respectively, and antecedent flu-like symptoms in 43%. a history of hypertension was observed in 35%, habitual alcoholism in 49% and diabetic pattern on glucose tolerance test in 37%. We then classified the study patients into three groups; familial, myocarditic and acquired groups. The familial group showed advanced myocardial damage with the poorest prognosis. Abnormal T-cell subsets in this group suggested that genetically determined abnormal immune response is involved in the development of DCM. In the myocarditic group, endomyocardial biopsy demonstrated mononuclear cell infiltration in 53% and the myocardial damage and prognosis were of intermediate severity. The acquired group showed significantly more frequent histories of hypertension, habitual alcoholism or diabetes than their age- and sex-matched controls, suggesting that they developed the disease in association with these factors. The severity of hemodynamic impairment and myocardial damage was the least extensive and prognosis was relatively favorable in this group. These different clinical features in the three groups may provide evidence that these factors actually contribute to the development of myocardial damage in DCM and that the condition is a clinical syndrome associated with heterogeneous etiologies or conditioning factors. Determination and management of these factors would be of practical value in treating patients with DCM that has no established therapy against underlying etiologies.
- 社団法人日本循環器学会の論文
- 1987-06-20
著者
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ADACHI KYO
Japanese Circulation Society(JCS)Task Force Committee on Chronic Myocarditis
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Adachi Kyo
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Adachi Kyo
The Institute Of Cardiovascular Diseases Kurume University School Of Medicine
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Koga Yoshinori
The Institute of Cardiovascular Diseases, Kurume Univ., Kurume, Japan
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Koga Yoshinori
The Institute Of Cardiovascular Disease Kuruue University Schcool Of Medicine
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Koga Yoshinori
Institute Of Cardiovascular Diseases Kurume Univ. School Of Med.
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TOSHIMA HIRONORI
The Department of Immunology, Kurume University School of Medicine
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TAKAMOTO TETSURO
The Department of Immunology, Kurume University School of Medicine
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YOKOYAMA MITCHEL
The Department of Immunology, Kurume University School of Medicine
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Adachi Kyoh
The Institute Of Cardiovascular Diseases Kurume University School Of Medicine
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Yokoyama M.mitsuo
The Department Of Immunology Kurume University School Of Medicine
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Toshima Hironori
The 3rd Dept. Of Int. Med. Kurume Univ. School Of Med.
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Koga Yosinori
3rd Department Of Internal Medicine Kurume University School Of Medicine
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Takamoto Tetsuro
The Department Of Immunology Kurume University School Of Medicine
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Toshima Hironori
The 3rd Department Of Lnternal Medicine Kurume University Medical School
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