EFFECTS OF ORAL BEFUNOLOL ON HEART RATE AND SYSTOLIC BLOOD PRESSURE DURING SUBMAXIMAL EXERCISE IN MAN
スポンサーリンク
概要
- 論文の詳細を見る
For the purpose of determining exercise intensity required for evaluating the effect of β-blocking agents, the multi-stage treadmill exercise was carried out up to intensity of 85% of maximal oxygen intake (V^^・O_2 max) after administration of β-blocking agents in 7 healthy men. To obtain a stable dose response in the inhibitory effect of β-blocking agents on heart rate (HR) and systolic blood pressure (S-BP), the exercise intensity more than 65% of V^^・O_2 max (75% of maximal heart rate) was needed. In order to evaluate the effect of befunolol (BFE), a submaximal treadmill exercise of 75% of the age adjusted predicted maximal heart rate was loaded in 6 healthy men at 1, 5, 4, and 8 hours following a single oral administration of 10 mg, 20 mg or 40 mg of BFE and 20 mg or 40 mg of propranolol. Simultaneously, the plasma concentration of BFE was determined 1, 5, 4, 6 and 8 hours after the administration of BFE at each dose. In human serum, BFE was detected together with its metabolite, revealing a significant correlation between BFE and metabolite (r = 0.94, p<0.001). Almost a certain rate of metabolite (4-5 times) was detected against BFE. As for the biological half life, it was 1.79±0.13 hours with BFE and 3.67±1.33 hours with metabolite. The inhibitory effect of BFE on HR and S-BP during exercise exhibited a dose response with the oral dose and its plasma concentration, and was almost twice as much as that of propranolol at the same dose. Accordingly, the myocardial oxygen consumption which may be represented as a rate pressure product was inhibited twice as much as propranolol. BFE is characteristic of its more rapid elimination of its effect compared to the other β-blocking agents. The decrease in the inhibitory effect of BFE on HR during exercise was about 1.8 times quicker than that of propranolol.
- 社団法人日本循環器学会の論文
- 1980-11-20
著者
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Toshima Hironori
The Third Department Of Medicine Kurume University School Of Medicine
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Terasawa Masahisa
The Third Department of Internal Medicine, Kurume University School of Medicine
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Furusho Yohzo
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Itaya Kenichi
The 3rd Dept. Of Int. Med. Kurume Univ. School Of Med.
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Miki Nobushige
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Matoba Tsunetaka
The 3rd Department Of Internal Medicine Kurume University School Of Medicine
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Matoba Tsunetaka
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Matoba Tsunetaka
The Third Department Of Internal Medicine
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Itaya Kenichi
The Third Department of Internal Medicine Kurume University School of Medicine
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Midorikawa Keiichi
3rd Department of Internal Medicine
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MIDORIKAWA KEIICHI
The Third Department of Internal Medicine, Kurume University School of Medicine
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KUMAGAI EIICHIRO
The Third Department of Internal Medicine, Kurume University School of Medicine
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IHARA SHOTOMI
The Third Department of Internal Medicine, Kurume University School of Medicine
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Toshima Hironori
The Third Departmelet Of Internal Medicine Kurume University Medical School Kurume
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Itaya Ken-ichi
3rd Dept. Of Intern. Med. Kurume Univ. School Of Med.
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Kumagai Eiichiro
The 3rd Dept. Of Intern. Med. Kurume Univ. School Of Medicine
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Terasawa Masahisa
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Miki Nobushige
Cardiovascular Research Institute Kurume Univ. School Of Med.
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Miki Nobushige
The 3rd Dept. Of Intern. Med. Kurume Univ. School Of Med.
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Ihara Shotomi
The Third Department Of Internal Medicine Kurume University School Of Medicine
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Kumagai Eiichirou
Third Department Of Internal Medicine Kurume University School Of Medicine
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Furusho Yozo
The 3rd Dept. Of Intern. Med. Kurume Univ. School Of Med.
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