チアノーゼを有する先天性心疾患における胃病変

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The purpose of this paper is to report the histopathological findings and quantitative evaluation of glomerular enlargement in the kidney from patients with cyanotic congenital heart disease. Comparison between morphological changes of kidneys and certain clinical findings was also attempted. Material and Method Histological examination and histometrical measurements of glomerular size were performed in thirty-six kidneys from congenital cyanotic heart disease. Included were' 25 patients with tetralogy of Fallot, 3 with transposition of great vessels, 3 with truncus arteriosus and 5 with miscellaneous cardiac malformations with cyanosis. They ranged in age from 7 days to 29 years, with an average of 8.5 years. Thirty-three control cases were selected, at random from the autopsy files, as fulfilling the following criteria of "normality" : the absence of congenital heart disease; the presence of both kidneys without significant rend disease: the absence of congestive heart failure and blood dyscrasia. These cases were chosen to cover the age range from newborn to 27 years with an average age of 9.1 years. Two sections of each kidney were reviewed. Tissues were fixed in 10 per cent formalin and embedded in paraffin. All preparations were stained with hematoxylin and eosin and peridic acid-Schiff. Technique of Measurement: A measure of average glomerular size was performed in each case by means of an optical micrometer. Two linear measurements were made for each of 100 glomeruli with apparent vascular poles. The first measurement "A" was the maximum distance across Bowman's capsule : the second, "B", the maximum distance across Bowman's capsule at right angles to the first measurement. A cross-sectional glomerular area was calculated by 1/4πAB. For statistical analysis, P≤0.01 was considered to be significant.
社団法人日本循環器学会の論文
1969-06-20

チアノーゼを有する先天性心疾患における胃病変

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