冠状動脈血栓と内膜の破綻

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It was reported for a long that break was found in the intima under coronary thrombus. Some authors^<14-17> reported recently that the rupture of the intima would be important as the cause of coronary thrombosis. The present study was undertaken to investigate the incidence of coronary thrombus with ruptured intima, morphogenesis of the thrombus and causes of the rupture of the intima. Materials and Methods After fixation in 10% formalin, coronary arteries were sectioned transversely at 2-5 mm intervals. When thrombus or severe intramural hemorrhage was found, transverse sections were made at longer intervals and as parallel as possible. Calcified arteries were removed and decalcified before the sectioning. Serial blocks were removed so that the thrombus or the intramural hemorrhage would be included as a whole. The blocks were processed through alcohol, xylol and paraffin, and sectioned serially at 5μ with AO Spencer No. 820 rotary microtome. Incomplete sections at the beginning were stained with hematoxylin and eosin, and all of the other sections were numbered. Sections numbered 1,6,... were stained with hematoxylin and eosin. Those numbered 2,7,... were stained with elastica Van Gieson and those numbered 3,8,... were stained with Mallory azan method. Other sections were preserved. Thus, 22 thrombosed coronary segments were obtained from 17 cases (12 of whom were male), aged 29 to 90 years. Results In all of the 22 specimens, marked atherosclerotic thickening of the intima was found. Stenosis rate of 12 specimens were 76% or over and that of the rests were 51 to 75%. Nine specimens had breaks of the intima under the thrombus. Five of them had two or more rents (Table I).
社団法人日本循環器学会の論文
1976-05-20

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