The Role of Na^+/H^+ Exchange in Norepinephrine-induced Protein Synthesis in Neonatal Cultured Rat Cardiomyocytes : 53th Annual Scientific Session of the Japanese Circulation Society
スポンサーリンク
概要
- 論文の詳細を見る
It is reported that Na^+ influx contributes to stretch-induced cardiac hypertrophy. Na influx may also be involved in cardiac hypertrophy induced by catecholamine. In the present study, to test whether Na^+/H^+ exchange plays an important role in norepinephrine-induced cardiac hypertrophy, the effect of Na^+/H^+ exchange inhibitor, amiloride on protein systhesis was studied in cultured neonatal rat cardiomyocytes in serum free medium. [^3H]Phenylalanine uptake was determined 24 and 48 hours after administration of norepinephrine with and without amiloride. In the control, norepinephrine increased [^3H]phenylalanine uptake in a dose dependent manner (10^<-5>-10^<-7> M). Prazosin (10^<-7> M) and amiloride (10^<-5>-10^<-4>M) significantly attenuated the norepinephrine mediated protein synthesis. These results indicate that α_1-adrenergic stimulation enhances the protein synthesis through activation of Na^+/H^+ exchange. Therefore, Na^+ influx and/or PH increase may play a key role in cardiac hypertrophy.
- 社団法人日本循環器学会の論文
- 1990-05-20
著者
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Imai Katsuji
Cardiovascular Center Sakurabashi Watanabe Hospital
-
Inoue Katsumi
松江赤十字病院 循環器科
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Kamada Takenobu
The First Department Of Medicine And The Department Of Medical Information Science
-
Kitabatake Akira
The First Department Of Medicine Osaka University School Of Medicine
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Kitabatake Akira
From The Division Of Cardiology First Department Of Medicine And The Department Of Pathophysiology O
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Tsujioka Katsuhiko
The First Department Of Medicine Osaka University Medical School
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Kitabatake A
Hokkaido Univ. Sapporo Jpn
-
HORI MASATSUGU
The First Department of Medicine, Osaka University Medical School
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NAKATSUBO NOBUAKI
The First Department of Medicine, Osaka University Medical School
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KAGIYA TOSHIFUMI
The First Department of Medicine, Osaka University Medical School
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IWAI KUNIMITSU
The First Department of Medicine, Osaka University Medical School
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SATO HIROSHI
The First Department of Medicine, Osaka University Medical School
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IWAKURA KATSUOMI
The First Department of Medicine, Osaka University Medical School
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Arai Kazutaka
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
-
Kamada Takenobu
1st Dept. Of Med. Medical School Osaka University
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Kagiya Toshifumi
The First Department Of Medicine Osaka University Medical School
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Ko Toshikatu
National Institute Of Basic Biology Osaka Univ.
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Kitabatake Akira
First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M
-
Iwai Kunimitsu
The First Department Of Medicine Osaka University Medical School
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Nakatsubo Nobuaki
The First Department Of Medicine Osaka University Medical School
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Hori Masatsugu
The First Department Of Medicine Osaka University Medicial School
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Kajita Tomomichi
Ist Div. Dept. Of Med. (prof. T. Yoshida) Osaka Univ. Hosp. Osaka University Med. School Osaka
-
Kajita Tomomichi
1st Division Dept. Of Intern. Med. Osaka Univ. Sch. Of Med.
-
Hori Masatsugu
The First Department Of Medicine And The Department Of Medical Information Science
-
Kagiya Toshifumi
The First Dept. Of Med. Osaka Univ School Of Med.
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Kitabatake A
Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine
-
KAMADA Takenobu
the First Department of Internal Medicine, Osaka University Medical School
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