Quantitative Assessment of Daily Physical Activity Levels in Patients With Chronic Heart Failure by Measuring Energy Expenditure : Effects of Converting Enzyme Inhibitor Therapy
スポンサーリンク
概要
- 論文の詳細を見る
Although a major goal in the treatment of chronic heart failure is to improve daily physical activity levels, this has not been assessed quantitatively. An increased daily activity level may be reflected by an increase in daily energy expenditure. In the present study, measurements of energy expenditure with a commercially available ambulatory calorimeter were first validated using cardiopulmonary exercise tests in 5 normal volunteers. The energy expenditure measured by the calorimeter correlated well with that estimated from oxygen uptake(r=0.89). Subsequently, the daily energy expenditure was serially measured with the calorimeter during long-term administration of the converting enzyme inhibitior ramipril for 24 weeks in 8 patients with chronic heart failure. Changes in echocardiographic parameters and exercise capacity were also studied. Peak oxygen uptake and anaerobic threshold assessed with symptomlimited maximal bicycle exercise were significantly increased 12 weeks or more after the initiation of treatment(P<0.01 and P<0.01, respectively). Left ventricular fractional shortening substantially, but not significantly, increased during this period(P<0.1). These results strongly suggest that an overall improvement in heart failure was achieved after long-term ramipril therapy. The energy expenditure during daily activities was also significantly increased after ramipril therapy for 24 weeks(P<0.01). Thus, the daily energy expenditure increased with improvement of heart failure, probably reflecting an increase in daily activity levels. We conclude that calorimetric measurement of daily energy expenditure is a novel and simple technique for quantitative evaluation of the effect of therapy on daily physical activity levels in patients with chronic heart failure.
- 社団法人日本循環器学会の論文
- 1995-09-20
著者
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Suga H
Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine
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Imai Katsuji
Cardiovascular Center Sakurabashi Watanabe Hospital
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Kamada Takenobu
The First Department Of Medicine And The Department Of Medical Information Science
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HORI MASATSUGU
The First Department of Medicine, Osaka University Medical School
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Inoue Michitoshi
Osaka Univ. School of Med
-
Inui Makoto
First Department Of Medicine And Department Of Pathophysiology Osaka University School Of Medicine
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Inoue M
Division Of Cardiology Osaka National Hospital
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Sato Hideyuki
The First Department of Medicine and the Department of Medical Information Science
-
Ozaki Hitoshi
The First Department of Medicine and the Department of Medical Information Science
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Yokoyama Hiroshi
The First Department of Medicine and the Department of Medical Information Science
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Imai Katsuji
The First Department of Medicine and the Department of Medical Information Science
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Katsube Yoshiki
The First Department of Medicine and the Department of Medical Information Science
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Morikawa Masa-aki
The First Department of Medicine and the Department of Medical Information Science
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Inoue Michitoshi
Osaka National Hospital
-
Yoshimura Hiroyuki
Nippon Zohki
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Inoue Michitoshi
Osaka University School Of Medicine
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Inoue Michitoshi
The First Department Of Medicine Osaka University Medical School
-
Kamada Takenobu
1st Dept. Of Med. Medical School Osaka University
-
Kawashima Y
First Department Of Surgery And Department Of Physiological Chemistry Osaka University Medical Schoo
-
Kawashima Yasunaru
First Department Of Surgery And Department Of Physiological Chemistry Osaka University Medical Schoo
-
Kobayashi Yasuhiko
Division Of Cardiovascular Surgery Osaka Minami National Hospital
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Hori Masatsugu
The First Department Of Medicine Osaka University Medicial School
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Inoue Michitoshi
First Department Of Medicine And Department Of Pathophysiology Osaka University School Of Medicine
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Inoue M
Osaka National Hospital
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Matsuo Hirohide
Department Of Cardiology Osaka University Graduate School Of Medicine
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Higashino Yorihiko
The Cardiovascular Division Of Osaka Police Hospital Osaka University
-
Hori Masatsugu
The First Department Of Medicine And The Department Of Medical Information Science
-
KAMADA Takenobu
the First Department of Internal Medicine, Osaka University Medical School
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