Disruption of Microtubules in Cultured Neonatal Rat Cardiomyocytes During Rapid Contractions : Protective effects of beta-adrenoceptor antagonist : CURRENT THERAPY OF INTRACTABLE HEART FAILURE

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概要

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• Tachycardia may play a key role in the progression of heart failure probably through Ca^<2+> overload. In the present study, to test whether microtubules, Ca^<2+>-sensitive cytoskeletons, are disrupted by rapid contractions and whether the beta-adrenoceptor antagonist, propranolol could attenuate the disruption of microtubules, cultured neonatal rat cardiomyocytes with various contraction rates were studied. The microtubules were stained by immunohistochemical technique and the extent of microtubule disruption was quantified by disruption scores (grade 0-intact; grade 3-severe disruption). In 97% of the non-contracting cells, intact microtubules (grade 0) were observed, whereas in the cells that contract at the rate of 100-120/min, intact microtubules were observed only in 25% of the cells. The disruption scores were significantly correlated with con-traction rates of the cells. Treatment with propranolol (10^<-6>M) decreased the extent of microtubule disruption associated with a decrease in the contraction rate. However, this treatment did not alter the relationship between the con-traction rate and the disruption score of microtubules. These results indicate that rapid contractions may induce disruption of microtubules which can be attenuated by beta-blocker mainly by its negative chronotropic effect. This may be one of the underlying mechanisms of the long-term effect of beta-blockers for chronic heart failure.

• 社団法人日本循環器学会の論文
• 1992-01-20

著者

• Suga H

  Department Of Cardiovascular Medicine Osaka University Graduate School Of Medicine

• Imai Katsuji

  Cardiovascular Center Sakurabashi Watanabe Hospital

• Kamada Takenobu

  The First Department Of Medicine And The Department Of Medical Information Science

• Kitabatake Akira

  Department Of Cardiovascular Medicine Hokkaido University School Of Medicine

• Kitabatake Akira

  The First Department Of Medicine Osaka University School Of Medicine

• Kitabatake Akira

  From The Division Of Cardiology First Department Of Medicine And The Department Of Pathophysiology O

• Kitabatake A

  Hokkaido Univ. Sapporo Jpn

• HORI MASATSUGU

  The First Department of Medicine, Osaka University Medical School

• IWAI KUNIMITSU

  The First Department of Medicine, Osaka University Medical School

• SATO HIROSHI

  The First Department of Medicine, Osaka University Medical School

• Takashima Seiji

  Department Of Cardiology Osaka University Graduate School Of Medicine

• Shimazu Takashi

  The First Department Of Medicine Osaka University School Of Medicine

• Inui Makoto

  First Department Of Medicine And Department Of Pathophysiology Osaka University School Of Medicine

• Inoue M

  Division Of Cardiology Osaka National Hospital

• Sato Hideyuki

  The First Department of Medicine and the Department of Medical Information Science

• INOUE MICHITOSHI

  The Medical Information Sciense, Osaka University School of Medicine

• TAKASHIMA SEIJI

  The First Department of Medicine, Osaka University School of Medicine

• Arai Kazutaka

  First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M

• Inoue Michitoshi

  Osaka University School Of Medicine

• Inoue Michitoshi

  The First Department Of Medicine Osaka University Medical School

• Kamada Takenobu

  1st Dept. Of Med. Medical School Osaka University

• Kitabatake Akira

  First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M

• Iwai Kunimitsu

  The First Department Of Medicine Osaka University Medical School

• Hori Masatsugu

  The First Department Of Medicine Osaka University Medicial School

• Inoue Michitoshi

  First Department Of Medicine And Department Of Pathophysiology Osaka University School Of Medicine

• Inoue M

  Osaka National Hospital

• Kitabatake Akira

  First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of M

• Hori Masatsugu

  The First Department Of Medicine And The Department Of Medical Information Science

• Kitabatake Akira

  First Department Of Medicine And Faculty Of Medical Information Science Osaka University School Of Medicine

• Kitabatake A

  Department Of Cardiovascular Medicine Hokkaido University Graduate School Of Medicine

• Arai Kazutaka

  From The Division Of Cardiology First Department Of Medicine And The Department Of Pathophysiology Osaka University School Of Medicine

• KAMADA Takenobu

  the First Department of Internal Medicine, Osaka University Medical School

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