Intravascular Ultrasound Imaging in Human Peripheral and Coronary Arteries in Vivo : ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES

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To detemine the feasibility of intravascular ultrasound imaging in vivo, a miniaturized high frequency transducer catheter was introduced into human peripheral (n=10) and coronary (n=4) arteries. Cross-sectional ultrasound images were obtained from iliofemoral arteries in 10 patients using a 20 MHZ transducer catheter (1.2 mm in diameter) and from coronary arteries in 4 patients using a 30 MHZ transducer catheter 5 French size (Fr) following successful coronary angioplasty. Ultrasound images obtained from peripheral arteries showed a three-layered appearance (echo-reflective intima, echo-lucent media and echo-reflective adventitia) in the normal arteries. In diseased arteries, the location, amount and extent of atheromatous plaque were clearly documented. The arterial diameters measured by ultrasound closely correlated with the measurements by angiography (r=0.91) in the peripheral arteries. Coronary angiograms obtained following balloon angioplasty revealed smooth edges at the dilatation sites without significant narrowing in all patients. However, a significant amount of residual atheromatous plaque was clearly observed on the ultrasound images at the previously dilated sites. Coronary dissection, which was identified as an echo-lucent area behind the plaque, was noted in 2 patients. Ultrasound images also revealed the presence of calcium in the plaque which was unrecognized on the angiograms in 3 patients. In addition, direct measurement of the lumen cross-sectional area was possible on the ultrasound images. These results indicate that (1) the clinical use of intravascular ultrasound imaging catheters is feasible in human peripheral and coronary arteries in vivo, (2) both quantitative and qualitative assessments of atheromatous plaque are possible, and (3) this device will be useful for determining the quantitative and morphologic changes following coronary angioplasty.
社団法人日本循環器学会の論文
1992-06-20

Intravascular Ultrasound Imaging in Human Peripheral and Coronary Arteries in Vivo : ADVANCES IN IMAGING TECHNIQUES FOR DIAGNOSIS OF CARDIOVASCULAR DISEASES

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