The effects of lidocaine and verapamil on overdrive-induced suppression of pacemakers in dogs with complete atrioventricular block.
スポンサーリンク
概要
- 論文の詳細を見る
When the ventricle is electrically stimulated at a faster rate, the cessation of the drive is followed by a temporary suppression of automaticity (overdrive suppression). The effects of lidocaine and verapamil on overdrive suppression were studied in dogs. Lidocaine slowed the ventricular escape rate and prolonged the pause following overdrive; occasionally, it was about twice the next succeeding RR interval. On the contrary, verapamil influenced neither the ventricular escape rate nor the pause following overdrive. It is suggested that lidocaine not only suppresses the automaticity of ventricular escape pacemaker but also induces exit block and that the spontaneous depolarization of the ventricular pacemaker is not slow channel-dependent.
- International Heart Journal刊行会の論文
著者
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Saito Satoshi
Second Department of Internal Medicine, Nihon University School of Medicine
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Watanabe Ichiro
Second Department of Medicine, Nihon University School of Medicine
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Takahashi Nobuhiro
Second Department of Internal Medicine, Nihon Univ. School of Medicine
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Ozawa Yukio
Second Department Of Internal Medicine Nihon University School Of Medicine
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Hatano Michinobu
Second Department Of Internal Medicine Nihon University School Of Medicine.
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Tanigawa Naoshi
Second Department Of Internal Medicine Nihon University School Of Medicine
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TAKAHASHI Nobuhiro
Second Department of Internal Medicine, Nihon University School of Medicine
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OZAWA Yukio
Second Department of Internal Medicine, Nihon University School of Medicine
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HATANO Michinobu
Second Department of Internal Medicine (Department of Cardiology, Surugadai Nihon University Hospital)
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