AGE-ASSOCIATED MYOCARDIAL CHANGES IN VARIOUS HEART DISEASES : A Clinicopathologic Analysis in Biopsied and Autopsied Myocardium : SYMPOSIUM ON LONG-TERM MYOCARDIAL CHANGES IN HEART DISEASES : 49th Annual Scientific Session of the Japanese Circulation Soci

概要

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Age-associated changes in histopathologic and ultrastructural aspects of cardiac myocytes were systematically compared with clinical problems. The study material consisted of 1,515 endomyocardial biopsies ; 150 normal and 50 diseased cardiac myocytes from pediatric autopsy specimens ; 34 intra-operative endomyocardial biopsy specimens from the left ventricle and 28 surgical biopsy specimens from the right or left atrium. The following results were obtained : 1) The myocytes developed to adult size by the age of 15 years. Thereafter, the size did not change up to the age of 59. 2) Short-term hemodynamic overloading to the ventricle caused reactive hyperfunction and hypertrophy of myocytes. Stable hypertrophy resulted in long-term overloading. 3) In cardiomyopathy, compensated or stable hypertrophy occurred but sclerosis (Meerson) took place. Progress of endocardial thickening was often observed during the course of the disease. 4) In the right and left atrial myocardium, extremely advanced pathology was observed and changes were related to the duration of the disease rather than to the severity of the hemodynamics.
社団法人日本循環器学会の論文
1986-10-20