Analysis of Histopathologic Findings in Cases with Dilated Cardiomyopathy with Special Reference to Formulating Diagnostic Criteria on the Possibility of Postmyocarditic Change : THE 10th CONFERENCE ON THE 10th CONFERENCE ON PREVENTION FOR RHEUMATIC FEVER
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概要
- 論文の詳細を見る
From our study employing serial endomyocardial biopsy in patients with acute viral or idiopathic myocarditis, we were able to construct histopathologic criteria for acute, subacute and convalescent myocarditis. We realize that it is difficult for the inexperienced observed to make an appropriate diagnosis of myocarditis or postmyocarditic changes in patients with dilated cardiomyopathy (DCM). In order to overcome this problem, each finding was graded and the scores obtained were analyzed statistically and compared with those from hypertrophic cardiomyopathy (HCM) and chronic right ventricular overloading (CRVO). The scores were obtained by summing the gradings for each of the following findings : increase of fibrocytes, increase of fibroblasts in the interstitium, hypertrophy of myocytes, fragmentation of muscle bundles, interstitial fibrosis, disarrangement of muscle bundles, abnormal branching, variation in size, increased glycogen deposition in the sarcoplasm, scarcity of myofibrils, and nuclear degeneration of myocytes and endocardial thickening. Since the increase in number of fibrocytes was considered important, its value was doubled. Scores in each group were as follows : convalescent myocarditis : 17.1 ± 4.7 (n=10), DCM : 13.2 ± 3.3 (n=47), HCM : 9.7 ± 2.4 (n=20), CRVO : 7.0± 3.6 (n=21). It was found that the scores for cases with myocarditis in the convalescent stage and in DCM were higher than those found for cases with either HCM and CRVO (p < 0.05). In summary, the high score for postmyocarditis in DCM could suggest that prior myocarditis is an important causative factor of this disease.
- 社団法人日本循環器学会の論文
- 1986-12-20
著者
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Hasumi Motonari
Department Of Radiology & Cardiology Tokyo Women's Medical College The 1st Department Of Me
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Yu Zu-xi
The Heart Institute Of Japan Department Of Radiology And Endocrinology Tokyo Women's Medical Co
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Sekiguchi Morie
The Heart Institute, Tokyo Women's Medical College
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Hirosawa Koshichiro
The Heart Institute of Japan, Tokyo Women's Medical College
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Morimoto Shin-ichiro
First Department Of Internal Medicine Shinshu University
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Hasumi Motonari
The Heart Institute Japan Tokyo Women's Medical College
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Hiroe Michiaki
The Heart Institute of Japan, Tokyo Womens' Medical Collage and Institute of Statistical Mathematics
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Hasumi Motonari
The Heart Institute Of Japan
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Hirosawa Koshichiro
The Heart Institute Japan Tokyo Women's Medical College
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Hiroe Michiaki
Second Department Of Internal Medicine Tokyo Medical And Dental University
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Yu Zu-xi
Tokyo Women's Medical College
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Hasumi Motonari
Department Of Radiology Cardilogy & Cardiovascular Surgery Tokyo Women's Medical College &a
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Hasumi Motonari
Departments Of Cardiology Tokyo Women's Medical College
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Sekiguchi Morie
The Heart Institute Of Japan
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Hiroe Michiaki
The Heart Institute Of Japan Tokyo Women's Medical College
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Sekiguchi Morie
International Cardiomyopathy Study Section Japan Research Promotion Society For Cardiovascular Disea
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Sekiguchi Morie
International Cardiomyopathy Study Section Japan Research Promotion Society For Cardiovascular Disea
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