40. フラボノイドの構造とラット網膜神経節細胞酸化ストレスに対する神経保護作用

概要

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Retinal ganglion cell death is the final pathological pathway of glaucomatous optic neuropathy. Many factors -elevated IOP, hypoxia, oxidative stress, nitric oxide, deprivation of trophic factors, glutamate, autoimmunity, heredity, and the other factors- have been related to the pathogenesis of glaucoma. A few reports revealed that some anti-oxidative compounds exist and they can be effective against oxidative-stress induced RGC death. Flavonoids, which are widely present in plants, have anti-oxidative effect. It has been reported that flavonoids have the inhibitory effects on the proliferation of HIV and the carcinogenesis of some specific cells. However, the neuroprotective effect of flavonoids on RGC death has not been clarified. Purpose of this study is to evaluate the therapeutic potential of flavonoids, we investigated the neuroprotective effects on purified cultured retinal ganglion cells (RGCs) suffering from oxidative stress. The neuroprotective effects of flavonoids can be attributed to their anti-oxidative ability intervening the pathway of oxidative stress-induced cell death. The relationship between structures and anti-oxidative activities of flavoids are worth exploring and evaluating in the future. Our results revealed that flavonoids, as a kind of flavonol agents, have direct neuroprotective effects against oxidative stress-induced RGC death.
2005-10-13