ラット adjuvant disease におよぼす新生期胸腺摘出の影響

概要

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A group of 12 female rats (Wistar King A) were thymectomized within 24 hours after birth and another group (10 sham thymectomized) were handled in the identical fashion except that the thymus was left in situ. Each of the animals received a suspension of heat killed tubercle bacilli (0.3 mg) in mineral oil (Drackeol 0.1 ml) in the left hind footpads. The following results were obtained. 1) In the incidence of the adjuvant disease, there was no significant difference between the thymectomized and the sham thymectomized group. 2) In the mean average days of onset and severity of local lesions induced at the injection site, there was no difference between the groups. 3) The lesions other than the local ones were milder and 5 to 7 days later in onset in the thymecomized group than in the sham thymectomized. These findings suggest that the local lesions were caused primarily by the toxic effect of the adjuvant while those induced at other sites probably by the secondary effect of the adjuvant were dependent upon some immunologic reactions related to the thymic function.
日本アレルギー学会の論文
1966-04-30