免疫学的機序による貧血の実験的研究 : 第1篇抗赤芽球抗体の末梢血液並びに骨髄像に及ぼす影響について

概要

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It is well known that a part of the aplastic anemias may occur with the immunologic mechanisms. Then, to make the experimental immune hypoplastic antibody against the rabbit's erythroblast was prepared by injecting it into guinea pigs, and this anti-rabbit erythroblast antibody was absorbed by rabbit's erythrocytes. The antibody was intravenously given and its damaging effects on the erythron were observed. 1) Some non-hemolytic anemia and slight hypoplasia in the bone marrow were recognized. 2) Both direct and indirect Coombs test were all negative in these rabbit. 3) The intravenous injection of ^<131>I-labeled anti-erythroblast antibody into the rabbits resulted in a high specific in vivo localization in the bone marrow, indicating the presence of localzing antibody. 4) It was seen by the method of microradioautograph with ^3H-Thymidine that the antibody inhibited the proliferative activity of erythroblasts in vitro. 5) Discussing the result in connection with the human pathology, there is a similarity of the hematologic figure produced in the author's experiments to a kind of the pure red cell anemias.
日本アレルギー学会の論文
1965-10-30