蛔虫アレルギーにおける抗原および抗体に関する研究 : 第13報胃, 十二指腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

概要

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In the previous paper the results of tanned cell hemagglutination test with ascaris body fluids in human intestinal ascariasis are reported. The present paper shows the results of the same experiment preformed on patients with gastro-duodenal ascariasis to trace the change in the hemagglutinin titer. At the attack, the hemaggltutinin titers in different age groups were as follows: Two preschool children showed the titer of 1:320 and 1:1,280; two elementary shool children showed the titer of 1:128 and 1:1,024; and one adult gave the titer of 1:640. Compared with the hemagglutinin titer of ascaris carriers in each age group, all the cases showed higher levels. Further, four showed the higher levels than patients with intestinal ascariasis, and the remaining one showed the same level with them. In the reconvalescence, the hemagglutinin titers in different age groups were as follows: Two preschool children showed the titer of 1:160, and one elementary school child 1:256. The hemagglutinin titer was lower than at the attack in all the three cases. Comparison in corresponding age groups revealed that all the cases were on higher level than both ascaris carriers and patients with intestinal ascariasis in reconvalescence. These patients were subjected to anthelmintic treatment, and the hemagglutinin titer was determined. The titers after anthelmintic treatment; two infants showed the titers 1:80 and 1:160, one elementary school child 1:256 and one adult 1:160. In one of the three cases, the titer was lowered, and in the other two, it remained unchanged. Comparison in corresponding age groups revealed that three out of the four showed the higher level than ascaris carriers, and one showed the same level with them; and further that all the cases showed the higher levels than patients with intestinal ascariasis after anthelmintic treatment. In this way, the hemagglutinin titer was higher at the attack of gastro-duodenal ascariasis, lowered in reconvalescence, and unchanged or lowered after anthelmintic treatment. And even after the treatment, the titer maintained at the level of about 1:160; evidently higher than intestinal ascariasis after treatment (1:20〜1:40). The hemagglutinin titer thus followed a definite course of change from the onset through succeeding stages of gastro-duodenal ascariasis, giving one more strong evidence to susport the assumption that ascariasis is principally based on an allergic reaction due to ascaris infection. Fur ther, the titer in gastro-duodenal ascariasis was higher than in intestinal ascariasis at the attack, in reconvalescence, or after anthelmintic treatment. Especially, the evidently high titer in the noninfected state after the treatment seemed to suggest that gastro-duodenal ascariasis was based on stronger sensitization and higher allergic state than the intestinal ascariasis.
日本アレルギー学会の論文
1962-02-28

著者

高橋良
群馬大学小児科学教室

蛔虫アレルギーにおける抗原および抗体に関する研究 : 第13報胃, 十二指腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

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蛔虫アレルギーにおける抗原および抗体に関する研究 : 第13報 胃, 十二指腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

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概要

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蛔虫アレルギーにおける抗原および抗体に関する研究 : 第13報胃, 十二指腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応