蛔虫アレルギーにおける抗原および抗体に関する研究 : 第12報小腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

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For the demonstration of circulating antibody in Ascaris-infected animals, precipitation, complement fixation tests and passive cutaneous anaphylaxis have been carried out. All of these, however, cannot clinically be utilized in ascaris-infection or ascariasis in man. In view of this, kuroume of this department, in 1956, demonstrated the human ascaris antibody with Boyden's tanned cell hemagglutination test. The results show that the hemagglutinin titer both in the infected and noninfected, was different in each age group, being lower in infants, rising with age, and attaining the level of the adult in middle school children. It was also found that the titer was remarkably higher in the infected than in the non-infected through all age groups. The author studied, the change in the hemagglutinin titer in patients with intestinal ascariasis, with his method and obtained the following results: 1) The titers at the attack: One out of five preschool children, showed the titer of 1:10, two was 1:80, one 1:160, and one 1:320. Out of four elementary school children, one was 1:320, and the other three 1:160. One middle school child was 1:160. In two adults, the titer was 1:160. Compared with the hemagglutinin titer in ascaris carriers in each age group, eight showed the higher, titer and four were the same level. 2) The titers in the reconvalescence: One out of three preschool children showed the titer of 1:20 and two 1:80; two elementary school children was 1:40 and one 1:80; one middle school child showed the titer of 1:80; and two adults were 1:40 and one 1:80. Compared with hemagglutinin titer in ascaris carriers in each age group, two were the higher level, five were the same level and one was the lower level. Compared with the hemagglutinin titer at the attack, the titer in the reconvalescence was found lower than at the attack in seven out of eight cases. 3) The titers after anthelmintic treatment: one preschool child was 1:20; two elementary school children was 1:20 and 1:40: one middle school child was 1:40; and one adult was 1:20. Comparison with the ascaris-noninfected in corresponding age groups revealed that two showed the higher and another three almost the same titer. Compared with the hemagglutinin titer in the reconvalescence, in four the titer was found to be lower after the anthelmintic treatment than in the reconvalescence. To summarize, the hemagglutinin titer in intestinal ascariasis was in general, higher at the attack, fell to the level of ascaris carriers in the reconvalescence, and fell further to the level of the noninfected after anthelmintic treatment. In this way, the titer showed a definite change from onset through the course of the disease, giving another evidence to support the assumption that ascariasis is principally based on allergic reaction due to ascaris infection.
日本アレルギー学会の論文
1962-02-28

著者

高橋良
群馬大学小児科学教室

蛔虫アレルギーにおける抗原および抗体に関する研究 : 第12報小腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

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蛔虫アレルギーにおける抗原および抗体に関する研究 : 第12報 小腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応

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蛔虫アレルギーにおける抗原および抗体に関する研究 : 第12報小腸蛔虫症患者における体腔液感作タンニン酸処理赤血球凝集反応