ウサギ抗 Benzyl Penicilloyl 抗体の結合型の Heterogeneity に関する研究
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1) Benzylpenicilloyl (BPO) groups were introduced into the bisdiazotized bezidine treated insoluble BGG aggregates. The aggregates were used for the analysis of site heterogeneity of rabbit anti-BPO antibody and 5 antibody populations were separated by elution with 5 haptens corresponding to the constituent of the BPO molecule. 2) By rechromatography and. PCA these antibody fractions were demonstrated to be specifically adapted to phenylacetic acic, phenylacetylglycine, 6-acetylaminopenicilloic acid, benzylpenicilloic acid, and benzylpenicilloyl-ε-aminocaproate (BPO-EACA) respectively. 3) The binding afiinity of the antibody directed to the whole BPO molecule was stronger than that of antibody directed to the smaller parts of the BPO molecule. 4) The cross-reactivity of anti-BPO antibody with penicilloyl drivatives of synthetic penicillins was examined. The fraction directed to the nuclear portion of the BPO molecule reacted as strongly with penicilloyl drivatives of synthetic penicillins as with BPO-EACA. The fraction adapted to the acyl side chain portion of the BPO molecule had various cross-reactivity with penicilloyl derivatives of synthetic penicillins. 5) The combining sites of γ G and γ M anti-BPO changed with time after the immunization. At a late stage of immune response a significant increase was observed in antibodies adapted to the whole BPO molecule. These changes of combining sites were more characteristic in γ G than in γ M.
- 1969-07-30
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