High Incidence of Malignant Lung Carcinomas in Rats after Inhalation of ^<239>PuO_2 Aerosol
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概要
- 論文の詳細を見る
Female Wistar strain rats were exposed to a single inhalation of a submicron-size aerosol of high-fired ^<239>PuO_2 to investigate pulmonary carcinogenesis during lifespan periods. The absorbed lung doses of the exposed anmals ranged from 0.6 to 12 Gy and were well correlated with the initial lung deposition (ILD) of 0.1 to 2.3 kBq. Survival and induction of primary lung tumors in 116 exposed rats were compared with those in 56 untreated control rats in respect to lung doses received. Mean survival time was greatly reduced, and the cumulative incidence of total lung tumors was markedly increased to 90-100% in rats that received more than 4 Gy, whereas of the controls only one animal (1.8%) died of primary lung tumors. Primary but benign adenomas were present in exposed animals given 1.0 Gy or less, and the incidence of adenomas was 22-25% at 4-5 Gy, but decreased sharply to 3-5% at 6-8 Gy. In contrast, no malignant carcinomas, including adenocarcinomas, adenosquamous carcinomas and squamous cell carcinomas, developed at a dose of less than 1.0 Gy, whereas they were present in 75% or more of the rats given 4-10 Gy, but only in 55% at 12 Gy. Although there were no clear differences in the dose and time required for induction among the carcinoma types , all tended to develope in earlier periods after inhalation than adenomas. Despite the limited number of exposed animals that received lower doses, results suggest that malignant lung carcinomas are highly and early induced and have a different dose-effect relationship than benign adenomas at doses of more than 1 Gy after inhalation exposure to ^<239>Pu0_2.
- 日本放射線影響学会の論文
著者
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小木曽 洋一
放射線医学総合研究所内部被ばく・防護研究部
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SATO HIROSHI
放射線医学総合県境所内部被ばく研究部
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INABA JIRO
放射線医学総合研究所内部被曝研究部
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YAMADA YUJI
放射線医学総合研究所内部被ばく研究部
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ISHIGURE NOBUHITO
放射線医学総合研究所内部被ばく研究部
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FUKUDA SATOSHI
放射線医学総合研究所内部被ばく研究部
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IIDA HARUZO
放射線医学総合研究所内部被ばく研究部
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YAMADA YUTAKA
放射線医学総合研究所内部被ばく研究部
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KOIZUMI AKIRA
放射線医学総合研究所内部被ばく研究部
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Inaba Jiro
放射線医学総合研究所内部被ばく研究部
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