Evaluation of the Effect of Gamma-irradiation on Fetal Erythropoiesis in Rats Using Blood Cell Volume as the Index
スポンサーリンク
概要
- 論文の詳細を見る
Rat fetuses at day 14 of gestation were irradiated externally with gamma rays at doses of 0.5-8 Gy, and the effect of radiation on the transfer of the erythropoietic site with migration of stem cells from the blood islands of the yolk sac into the liver was investigated. The LD_<50> was about 5 Gy for 16-day-old fetuses, 2 days after irradiation. Such fetal hematological parameters as the number of blood cells in the liver and the formation rate of micronuclei in erythrocytes, also were affected by irradiation. Two types of blood cells were present in the fetal circulating blood; small blood cells originating in the fetal liver and large blood cells originating in the blood islands of the yolk sac. The number of small blood cells in the circulating blood decreased with the increase in the radiation dose; but, the number of large blood cells remained relatively constant. This suggests that external doses of irradiation of more than 1 Gy impaired the normal transfer of the hematopoietic site (stem cell migration from the blood islands of the yolk sac into the liver).
- 日本放射線影響学会の論文
著者
-
Kubota Yoshihisa
放射線医学総合研究所内部被曝研究部
-
Kubota Yoshihisa
放射線医学総合研究所
-
SATO HIROSHI
放射線医学総合県境所内部被ばく研究部
-
KOSHIMOTO CHIHIRO
放射線医学総合県境所内部被ばく研究部
-
TAKAHASHI SENTARO
放射線医学総合県境所内部被ばく研究部
-
Takahashi Sentaro
放射線医学総合研究所内部被曝研究部
関連論文
- Transfer of ^Pu to mouse fetoplacental tissues
- Evaluation of the Effect of Gamma-irradiation on Fetal Erythropoiesis in Rats Using Blood Cell Volume as the Index
- Effect of γ-Irradiation on the Uptake and Digestion of ^I-labeled Bovine Serum Albumin by Rat Visceral Yolk Sac Cultured in vitro
- X-Ray Induced Apoptosis in the Organs of Mouse Fetus at Mid-Gestational Stage
- Detection of Radiation Induced Gene Mutation Using Muta^ Mouse
- Effect of ^Sr-Induced Monocytopenia on Splenic and Pulmonary Alveolar Macrophage Populations in a Normal Steady State
- Transfer of Plutonium to Rat Embryos in vivo and in vitro
- The Effect of External γ-Irradiation on ^Fe Release in vitro from Alveolar Macrophages Previously Having Ingested 59Fe-Iron Hydroxide Colloid
- High Incidence of Malignant Lung Carcinomas in Rats after Inhalation of ^PuO_2 Aerosol
- Fetoplacental Transfer of Plutonium Injected at Early Gestation Period
- Distribution of 14C in mouse conceptuses after maternal injection of 14C-glucose and 14C-amino acid mixture.
- Deposition Patterns of Plutonium in Mouse Liver after Intraperitoneal Injection of Plutonium Citrate
- Fetoplacental Transfer of Plutonium and the Effect on Fetal Henopoietic Function
- Evaluation of the effect of gamna irradiation on fetal erythropoiesis in rats by using the blood cell volune as the index
- Alteration of hemopoietic functions in the offspring of mice contaminated with ^Pu on day 13.5 of gestation.
- Non-uniform distribution of ^C in rat fetal brain after intravenous injection of ^C-thypridine on 13.5 days of gestation