An UVB-carcinogenesis Model with KSN Nude Mice
スポンサーリンク
概要
- 論文の詳細を見る
We established and characterized a systematic ultraviolet light-induced carcinogenesis model using KSN nude mice. We prepared five groups of KSN mice and exposed them six times a week to five levels of daily ultraviolet B (UVB) doses; 1340, 670, 320, 160 and 0 J/m^2 /day. In 670, 320 and 160 J/m^2 /day, the latency period tended to become shorter in proportion to the daily doses and prevalence data fitted well to log-normal distribution. In the log-log plot of days till 50% prevalence versus daily dose, we saw a linear relationship for 1mm tumor diameter. From this analysis, we determined that days necessary to reach 50% prevalence is in proportion to the -0.49 power of daily dose. The average number of tumors per survivor correlated with prevalence data. Direct measured rates of tumor growth were independent of daily UVB-dose. Therefore we speculated that UV-irradiation did not affect tumor growth after its appearance. Most UVB-induced tumors were squamous cell carcinoma, the rest were spindle cell carcinoma, papilloma and mixed type. We concluded that our experimental data with nude mice was in accordance with data with hairless mice in nature.
- 日本放射線影響学会の論文
著者
-
Suzuki Fumio
Fukujuji Hospital
-
Suzuki Fumio
Department of Cardiovascular Medecine,Tokyo Medical and Dental University
-
Suzuki Fumio
First Department of Internal Medicine
-
Suzuki Fumio
Department Of Cardiovascular Medecine Tokyo Medical And Dental University
-
Ishigaki Y
Laboratory Of Molecular Human Genetics Faculty Of Pharmaceutical Sciences Kanazawa University
-
Ishigaki Yasuhito
Department Of Radiation Biology Faculty Of Pharmaceutical Sciences Kanazawa University
-
Ishigaki Yasuhito
金沢大学 薬 分子細胞薬
-
Hiai H
Kyoto Univ. Kyoto Jpn
-
Hiai Hiroshi
Department Of Pathology And Biology Of Diseases Graduate School Of Medicine Kyoto University
-
Hiai Hiroshi
京都大学 医学研究科法医学
-
Hatano Hiromichi
Department Of Pathology And Biology Of Diseases Kyoto University Graduate School Of Medicine
-
NIKAIDO Osamu
Kanazawa Univ.
-
Hayakawa Jun-ichiro
Institute For Experimental Animals School Of Medicine Kanazawa University
-
Haga Hironori
Organ Transplant Unit Kyoto University Hospital
-
Nikaido O
Kanazawa Univ. Kanazawa Jpn
-
Nikaido Osamu
Laboratory Of Molecular Human Genetics Faculty Of Pharmaceutical Sciences Kanazawa University
-
Nikaido Osamu
Department Of Radiation Biology Faculty Of Pharmaceutical Sciences Kanazawa University
-
Nikaido Osamu
Division Of Radiation Biology Faculty Of Pharmaceutical Science Kanazawa University
-
Nikaido Osamu
Div. Radiation Biol. Kanazawa Univ.
-
Hiai Hiroshi
Department Of Medical Chemistry And Molecular Biology Kyoto University Graduate School Of Medicine
-
Haga Hironori
Laboratory Of Diagnostic Pathology Kyoto University Hospital
-
ISHIGAKI Yasuhito
Laboratory of Molecular Human Genetics Faculty of Pharmaceutical Sciences Kanazawa University
-
Hiai Hiroshi
Departments Of Pathology Graduate School Of Medicine Kyoto University
-
Nikaido Osamu
Div. Radiat. Biol. Fac. Of Pharm. Sci. Kanazawa Univ.
-
Suzuki Fumio
Mitsubishi Electric Corporation
-
Suzuki Fumio
Research Institute For Radiation Biology And Medicine Hiroshima University
-
Suzuki Fumio
Department Of Regulatory Radiobiology Research Institute For Radiation Biology And Medicine Hiroshim
-
Hiai Hiroshi
Laboratory Of Diagnostic Pathology Kyoto University Hospital
-
Suzuki Fumio
Division Of Cardiology Kawaguchi Kohgyo General Hospital
-
Suzuki Fumio
Tokyo Med. And Dental Univ.
-
Suzuki Fumio
Departent Of Materials Science And Engineering Faculty Of Engineering Yamagata University
関連論文
- Experimental atrial fibrillation originated from the pulmonary vein : Importance of vagal stimulation and driving force
- Diagnostic Significance of the Morphological Change in the Atrial Electrogram During Para-Hisian Pacing
- Demonstration of Phase-3 and Phase-4 Retrograde Block in a Second Concealed Accessory Pathway After an Initial Successful Radiofrequency Ablation of a 'Normal' Concealed Accessory Pathway
- -P245- Usefulness Of Para-Hisian Pacing For Detection Of Retrograde Conduction Over An Accessory AV Pathway : Comparison with Ventricular Extrastimulus During Tachycardia(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- ELECTROPHYSIOLOGIC STUDY ON ATRIO-NODAL INPUT(S) FROM THE LEFT ATRIUM: SIGNIFICANCE OF DISCREPANT "AH" INTERVALS FROM DIFFERENT LEFT ATRIAL SITES
- PARADOXICAL ATRIUM-HIS (AH) INTERVAL SHORTENING CAUSED BY PROXIMAL CORONARY SINUS STIMULATION DURING ORTHODROMIC RECIPROCATING TACHYCARDIA
- Hybrid pharmacologic and ablative therapy for atrial fibrillation : Long term observations after ablation of Ic-flutter
- The Response of the Slow Atrioventricular Nodal Pathway to Temperature
- Transcatheter Neodymium-Yttrium-Aluminum-Garnet Laser Coagulation of Canine Ventricle Using a Balloon-Tipped Cardioscope
- 0710 Catheter Ablation of Ventricular Tachycardia After Myocardial Infarction : Relationship of Endocardial Sinus Rhythm Late Potentials to the Reentry Circuit
- -P245- Usefulness Of Para-Hisian Pacing For Detection Of Retrograde Conduction Over An Accessory AV Pathway : Comparison with Ventricular Extrastimulus During Tachycardia(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- THE RESPONSE OF ATRIOVENTRICULAR JUNCTIONAL TISSUE TO TEMPERATURE
- -0911-ARRHYTHMIAS DURING CATHETER ABLATION OF THE AV JUNCTION IN DOGS : THE 54th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- -0278-MODIFICATION OF AV CONDUCTION BY ELECTRICAL CATHETER ABLATION
- THE SEQUENCE OF RETROGRADE ATRIAL ACTIVATION THROUGH THE ATRIOVENTRICULAR NODE : ANALYSIS WITH SIMULTANEOUS RECORDINGS OF THE ELECTROGRAMS OF THE LOW SEPTAL RIGHT ATRIUM AND THE ORIFICE OF THE CORONARY SINUS : Arrhythmias : 53 Annual Scientific Meeting, J
- -50- ELECTROPHYSIOLOGIC ASSESSMENT OF THE EFFECTS OF INTRAVENOUS BEPRIDIL ON CONDUCTION AND REFRACTORINESS IN THE HUMAN HEART : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 51th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Electrophysiological and Pharmacological Studies on the Mechanisms of Ventricular Tachycardia : SYMPOSIUM ON MECHANISM OF PAROXYSMAL TACHYARRHYTHMIAS : 49th Annual Scientific Session of Japanese Circulation Society
- A NEW METHOD FOR ASSESSING VENTRICULOATRIAL CONDUCTION IN THE HUMAN HEART : Arrhythmias (II) : FREE COMMUNICATIONS (III) : PROCEEDINGS OF THE 49th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Usefulness of Invasive and Non-invasive Electrophysiologic Studies in the Selection of Antiarrhythmic Drugs for the Patients with Paroxysmal Supraventricular Tachyarrhythmia : SYMPOSIUM ON INDICATION AND SELECTION OF ANTIARRHYTHMIC TREATMENT
- ELECTROPHYSIOLOGIC CHARACTERISTICS OF DIFFERENT FORMS OF ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA : Arrhythmias (II), Electrophysiology (II), Mapping : III : 48 Annual Scientific Meeting, Japanese Circulation Society
- ELECTROPHYSIOLOGIC STUDY ON THE ROLE OF A CONCEALED A-V NODAL BYPASS TRACT (ATRIO-HIS BYPASS FIBER) IN PATIENTS WITH A-V NODAL REENTRANT TACHYCARDIA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Electrophysiolog
- -Add. 82- EFFECTS OF APRINDINE ON ATRIO-VENTRICULAR REENTRANT TACHYCARDIA (AVRT) ASSOCIATED WITH WPW SYNDROME : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Cardiovascular Drugs (II)
- -P245- Usefulness Of Para-Hisian Pacing For Detection Of Retrograde Conduction Over An Accessory AV Pathway : Comparison with Ventricular Extrastimulus During Tachycardia(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- THE SEQUENCE OF RETROGRADE ATRIAL ACTIVATION THROUGH THE ATRIOVENTRICULAR NODE : ANALYSIS WITH SIMULTANEOUS RECORDINGS OF THE ELECTROGRAMS OF THE LOW SEPTAL RIGHT ATRIUM AND THE ORIFICE OF THE CORONARY SINUS : Arrhythmias : 53 Annual Scientific Meeting, J
- ELECTROPHYSIOLOGIC STUDY ON THE ROLE OF A CONCEALED A-V NODAL BYPASS TRACT (ATRIO-HIS BYPASS FIBER) IN PATIENTS WITH A-V NODAL REENTRANT TACHYCARDIA : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Electrophysiolog
- Demonstration of Phase-3 and Phase-4 Retrograde Block in a Second Concealed Accessory Pathway After an Initial Successful Radiofrequency Ablation of a 'Normal' Concealed Accessory Pathway
- -P245- Usefulness Of Para-Hisian Pacing For Detection Of Retrograde Conduction Over An Accessory AV Pathway : Comparison with Ventricular Extrastimulus During Tachycardia(PROCEEDINGS OF THE 59th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- Slow-fast Form of Atrioventricular Nodal Reentrant Tachycardia with Eccentric Retrograde Left-sided Activation
- CLlNICAL ELECTROPHYSIOLOGICAL STUDIES ABOUT THE MECHANISMS OF VENTRICULAR TACHYCARDIA : Arrhythmia : 46th Annual Scientific Meeting, Japanese Circulation Society
- PJ-612 Successful Cooling Ablation of Atrial Tachycardia Originating from Left Atrial Appendage Using a Conventional Angiographic Catheter(Arrhythmia, therapy(26)(A),Poster Session(Japanese),The 72nd Annual Scientific Meeting of the Japanese Circulation S
- -0319-EFFECT OF ATP ON SINO-ATRIOVENTRICULAR NODE AND CHANGES IN PLASMA LEVELS OF NUCLEIC ACID RELATED SUBSTANCES
- FAST-SLOW (UNCOMMON) FORM OF ATRIOVENTRICULAR NODAL REENTRANT TACHYCARDIA (AVNRT) : NEW CLASSIFICATION ACCORDING TO THE SITE OF THE RETROGRADE SLOW PATHWAY
- A STUDY ON THE REENTRY CIRCUIT OF THE A-V NODAL REENTRANT TACHYCARDIA : EVIDENCES AGAINST THE ATRIAL PARTICIPATION : Arrhythmia : 46th Annual Scientific Meeting, Japanese Circulation Society
- A simple ECG algorithm to guide pace mapping along the scar border identified by electroanatomical voltage mapping
- Spacial resolution of pace mapping using electroanatomical imaging in patients undergoing ablation of right ventricular outflow tract tachycadia
- Chemotherapy-Induced Sclerosing Cholangitis as a Rare Indication for Resection : Report of a Case
- Slow-fast Form of Atrioventricular Nodal Reentrant Tachycardia with Unusual Retrograde Activation in the Right Atrium : Possible Conduction Disturbance across the Tendon of Todaro Related to the Genesis of Positive Component of Biphasic Retrograde P Wave
- EXPERIMENTAL STUDY OF U WAVES IN DOGS : The Fifth Conference on Vectorcardiography
- THE ROLE OF ELECTRICAL INTERFERENCE IN THE GENESIS OF SINUS ARRHYTHMIA : Electrophysiology : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Society
- OJ-219 Abrupt Disappearance of Large Atrial Potentials at the Distal Coronary Sinus (CS) Strongly Suggests Loss of CS Musculature(Arrhythmia, Diagnosis/Pathophysiology/EPS 8 (A) : OJ25)(Oral Presentation (Japanese))
- SPATIAL MAGNITUDE OF THE UVECOTR IN ISCHEMIC HEART DEISEASE : THE IV CONFERENCE ON VECTORCARDIOGRAPHY
- N-RAS MUTATION DETECTED IN SPONTANEOUS NEOPLASTIC TRANSFORMATION OF CHINESE HAMSTER EMBRYO CELLS
- Port Site Metastasis of Sigmoid Colon Cancer After a Laparoscopic Sigmoidectomy : Report of a Case
- Effect of Space Flight on the Frequency of Micronuclei and Expression of Stress-responsive Proteins in Cultured Mammalian Cells
- Relative Biological Effectiveness of Accelerated Heavy Ions for Induction of Morphological Transformation in Syrian Hamster Embryo Cells
- Relative Biological Effectiveness of Accelerated Heavy Particles for Induction of In Vitro Transformation of Hamster Embryonic Cells.
- -75-CLINICAL STUDIES ON INSTABILITY OF THE RR INTERVALS IN PATIENTS WITH SICK SINUS SYNDROME : Arrhythmias : FREE COMMUNICATIONS(I) : PROCEEDINGS OF THE 53th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY
- Serotonergic Terminal Aggregation in The Somatosensory Cortex of Rat during Early Postnatal Period
- PROGRAMMED ELECTRICAL STIMULATION OF THE ATRIUM BY THE ESOPHAGEAL ELECTRODE : PROCEEDINGS OF THE 47th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIETY : Arrhythmia
- Electrophysiologic Evaluation of Antiarrhythmic Drugs on Supraventricular Tachyarrhythmias : Pharmacology and Clinical Evaluation of Antiarrhythmic Drugs
- CLINICAL ELECTROPHYSIOLOGIC STUDIES ON THE MECHANISM OF TERMINATION OF PAROXYSMAL SUPRAVENTRICULAR TACHYCARDIA BY ELECTRICAL STIMULATION AND VERAPAMIL : Arrhythmia : FREE COMMUNICATIONS (Abstract) : 45 Annual Scientific Meeting, Japanese Circulation Socie
- Current Status and Future Direction of Clinical Electrocardiography : His Bundle Electrogram : Present Status and Future of Clinical Electrocardiology
- ELECTROPHYSIOLOGICAL CHARACTERISTICS OF A-V NODAL REENTRANT TACHYCARDIA AND REENTRANT TACHYCARDIA UTILIZING A CONCEALED ACCESSORY PATHWAY : Arrhythmia・Electrophysiology : PROCEEDINGS OF THE 44th ANNUAL SCIENTIFIC MEETING OF THE JAPANESE CIRCULATION SOCIET
- -163-ELECTROPHYSIOLOGICAL PATTERNS OF VENTRICULOATRIAL CONDUCTION IN MAN : Arrythmia, His Bundle Electrogram , Electrophysiology : PROCEEDINGS OF THE 42nd ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- CLINICAL STUDY ON REENTRY INDUCED BY VENTRICULAR STIMULATION : IIIrd Auditorium
- EXPERIMENTAL ELECTROPHYSIOLOGICAL STUDIES ON SO-CALLED SINUS NODE REENTRY : IIIrd Auditorium
- CLINICAL ELECTROPHYSIOLOGICAL STUDIES ON SO-CALLED SINUS NODE REENTRY : IIIrd Auditorium
- STUDY OF SINUS NODAL AND ATRIAL FUNCTIONS IN THE CASES OF PAROXYSMAL A-V NODAL RE-ENTRANT TACHYCARDIA : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- ROLE OF THE HIS-PURKINJE SYSTEM ON INITIATION OF PAROXYSMAL TACHYCARDIA : Ist Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- SPATIAL MAGNITUDE OF THE VECTOR U LOOP IN RIGHT VENTRICULAR CONDUCTION DISTURBANCE AND OVERLOADING : THE III CONFERENCE ON VECTORCARDIOGRAPHY
- Electrophysiologic Study on Atrioventricular Nodal Reetrant Tachycardia--With Special Reference to Recent Controversies
- An UVB-carcinogenesis Model with KSN Nude Mice
- Usefulness of Bipolar and Unipolar Recordings in Coronary Sinus during Atrial Fibrillation to Differentiate Coronary Sinus and Left Atrial Potentials(Arrhythmia, Diagnosis/Pathophysiology/EPS 4 (A), The 69th Annual Scientific Meeting of the Japanese Circu
- 19)VECTOR U LOOP IN PATIENTS WITH IMPLANTED PACEMAKER : THE II CONFERENCE ON VECTORCARDIOGRAPHY
- MODE OF LONGITUDINAL DISSOCIATION OF A-V CONDUCTION SYSTEM : IVth Auditorium : PROCEEDINGS OF THE 40TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- INTERATRIAL PATHWAY ALONG THE A-V RING AT THE LOWER MARGIN OF THE LEFT ATRIUM IN THE HUMAN HEART
- MODE OF CONDUCTION FROM THE A-V NODE TO THE ATRIUM DURING RETROGRADE CONDUCTION : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- EXPERIMENTAL EVALUATION OF SOME CONTROVERSIAL POINTS ON THE A-V CONDUCTION DISTURBANCES IN THE CLINICAL HIS BUNDLE ELECTROGRAM : PROCEEDINGS OF THE 38TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- PROPERTIES OF THE CELL OF THE INTERATRIAL PATHWAYS ALONG THE ANTERIOR AND POSTERIOR PORTIONS OF THE LEFT A-V RING : PROCEEDINGS OF THE 37TH ANNUAL MEETING OF THE JAPANESE CIRCULATION SOCIETY
- MECHANISM OF VENTRICULAR ABERRANT CONDUCTION STUDIED EXPERIMENTALLY BY HIS BUNDLE ELECTROGRAMS
- A Use of Adaline as an Automatic Method for Interpretation of the Electrocardiogram and the Vectorcardiogram
- 5. Spatial Velocity Electrocardiograms of Normal and Abnormal Atrial Overloadings
- 46) Evaluation of the Dipole Concept for the Cardiac Electromotive Force According to the Intrinsic Component Theory
- 124. The Study on the Mechanism of Thyroid Effects to the Purkinje Fiber of the Heart by Microelectrode Technique
- Inactivation of NF-κB Mediates p53-dependent Apoptosis in X-irradiated Mouse Lymphoma Cells and Thymocytes
- Cyclin-Dependent Kinase 2 Activity after X-irradiation of Apoptosis-Sensitive and -Resistant Mouse Lymphonia Cell Lines
- Molecular Cloning of Cytoplasmic and Mitochondrial Thioredoxin Reductases from Mouse Thymocytes
- ELECTROPHYSIOLOGIC STUDIES ON THE ACTION OF DISOPYRAMIDE PHOSPHATE (DP) IN MAN : Arrhythmia II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- ELECTROPHYSIOLOGICAL STUDY ON SUPRAVENTRICULAR TACHYARRHYTHMIAS : Arrhythmia II : IInd Auditorium : Proceedings of the 43rd Annual Meeting of the Japanese Circulation Society, Tokyo, 1979
- SPATIAL VELOCITY ELECTROCARDIOGRAM OF THE VENTRICULAR PRESSURE AND VOLUME OVERLOAD. : (1) LEFT VENTRICULAR OVERLOAD. : PROCEEDINGS OF THE 35TH ANNUAL MEETlNG OF THE JAPANESE CIRCULATION SOCIETY (Part III)
- Pore Control of Microporous Silica Gel Obtained from Silica/Poly(ethylene glycol)Composite (膜とゲル 特集)
- A Method for Design of Embedded Systems for Multimedia Applications(Special Issue on Multimedia, Network, and DRAM LSIs)
- A method of FIR filter coefficient menory reduction using characteristic function model
- A method of FIR filter coefficient memory reduction using characteristic function model
- Top-Down Co-simulation of Hardware/Software Co-designs for Embedded Systems Based Upon a Component Logical Bus Architecture (Special Section on VLSI Design and CAD Algorithms)
- A Proposal for a Co-design Method in Control Systems Using Combination of Models : PAPER Special lssue on Synthesis and Verification of Hardware Design
- Suppression of Postmitochondrial Signaling and Delayed Response to UV-induced Nuclear Apoptosis in HeLa Cells
- Defect in Caspase Activation and the Delayed Response to UV-Induced Apoptosis in HeLa Cells
- Mitochondrial Release of Cytochrome c and AIF during the Apoptotic Process of Cultured Mammalian Cells
- Epidermoid cyst originating from an intrapancreatic accessory spleen
- THE MECHANISM OF CONTRACTION OF THE CARDIAC MUSCLE BY CATECHOLAMINE AND OUABAIN RELATION TO CHANGES OF ITS ACTION POTENTIAL
- 31. Ionic Transport Disturbance as Pathogenesis of Cardiac Fibrillation
- Modes of Action of New Antifibrillatory Drugs : Part II
- Abscess within a Glioblastoma Multiforme : Case Report
- Glutamate Receptor Antagonists and Benzodiazepine Inhibit the Progression of Granule Cell Dispersion in a Mouse Model of Mesial Temporal Lobe Epilepsy
- Subacute Subdural Hygroma and Presyrinx Formation After Foramen Magnum Decompression With Duraplasty for Chiari Type 1 Malformation : Case Report
- 酢酸セルロース-ジルコニア複合ゲル繊維へのウレアーゼの包括固定化
- シリカ/ポリビニルアルコ-ル複合体の延伸とその複合体より得られるシリカゲルの細孔構造
- A new method for assessing ventriculoatrial conduction in the human heart.
- Electrocardiographic masking of a myocardial infarction by a fasciculoventricular mahaim fiber, atrioventricular reentry with anterograde conduction over a fasciculoventricular mahaim fiber and retrograde conduction over a concealed kent bundle.