Recovery from Ultraviolet Light-Induced Depression of Ribosomal RNA Synthesis in Normal Human, Xeroderma Pigmentosum and Cockayne Syndrome Cells
スポンサーリンク
概要
- 論文の詳細を見る
The rate of ribosomal RNA (rRNA) synthesis was analyzed at different times after ultraviolet light (UV) irradiation in normal human, xeroderma pigmentosum (XP) and Cockayne syndrome (CS) cells. In normal cells, the rate of rRNA synthesis, as measured by the incorporation of ^3H-uridine into 185 and 28S rRNAs, decreased immediately after UV irradiation to about half of that of unirradiated cells, and then recovered significantly at 24 h after UV. However, the rate of synthesis continued to decrease during post-UV incubation in XP cells belonging to groups A, D, E, F and G, as well as in CS cells of groups A and B. In contrast, group C XP cells showed a slight recovery at 24 h after UV, suggesting that they have the capacity to repair UV lesions in rRNA genes.
- 日本放射線影響学会の論文
著者
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IKENAGA MITUO
Radiation Biology Center, Kyoto University
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HARA Ryujiro
Radiation Biol. Center, Kyoto Univ.
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AYAKI Hitoshi
Radiation Biol. Center, Kyoto Univ.
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AYAKI Hitoshi
Department of Public Health, Kobe University Graduate School of Medicine
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Ikenaga M
Radiation Biology Center Kyoto University
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Ikenaga Mituo
関西外国語大学
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Hara Ryujiro
Radiation Biology Center Kyoto University
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Ayaki H
Department Of Public Health Kobe University Graduate School Of Medicine
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Ayaki Hitoshi
Radiat. Biol. Center Kyoto Univ.
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Ikenaga Mituo
Radiat. Biol. Cent. Kyoto Univ.
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