Chemoprotection of Ovarian Follicles of Mice Against Gamma Irradiation by MPG (2-Mercaptopropionyiglycine)

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Adult virgin female Swiss albino mice were irradiated with 2.5, 5 and 10 Gy of gamma radiation in the presence and absence of the drug MPG and changes in the ovarian follicular population were scored at various post irradiation intervals of 3 hours to 14 days. The results indicate that the drug has partially prevented the rapid reduction in the follicular number. Primordial follicles are protected to a greater extent than the growing and large follicles. The difference between the number of follicles of drug treated and non-drug treated animals is greater at low dose group. It has been firmly established during the last quarter of a century that the harmful effects of ionizing radiation in biological systems including mammals, can be diminished either by pretreatment with certain chemicals or by selective modification of endogenus protective substances. A large number of chemical compounds have been shown to protect test animals against radiation injury and some have been found to raise the LD 50/30 quite considerably1-3). So far only β-Mercaptoethylamine has been shown to protect the ovaries against X-irradiation damage4). BAL (2:3 dimercaptopropanol) has also been found to provide some protection against internal irradiation5).
日本放射線影響学会の論文