Protection of Mouse Intestine against Gamma Irradiation by 2-Mercaptopropionylglycine (MPG)

概要

論文の詳細を見る
In a preliminary attempt to investigate the protective action of MPG on the tissues of mammals exsosed to high doses of ionizing radiations, adult Swiss albino mice were sLrbjected to 1,200R of gamma rays from a Co-60 source 30 minutes after a single intraperitoneal injection of 20 mg/kg body weight of the drug. The histopathological changes in the intestinal villi were studied at postirradiation intervals of 2, 5, 14 and 28 days and were compared with observations from mice irradiated in the absence of MPG. Severe damage was observed in the villi of the animals receiving no protective drug, whereas in the MPG injected group the villi were protected to some extent and an early recovery was effected with the result that the normal structure was restored by the last interval studied. Since the discovery of chernical radiation protection by Patt et al., many chemicals, including several sulfhydryl compounds, were tested for their protective action, some of which were found to be efficient protectors when administered before irradiation. But these compounds are needed in large doses, very near their toxic levels, for effective protection and hence their applicability in the clinical field is limited. Recently, Sugahara et al. have reported the discovery of a synthetic SH-compound, 2-mercapto-propionylglycine or MPG, which has a low toxicity.
日本放射線影響学会の論文