Difference in the Mechanism of Radioprotection between Carbon Particles and Bacterial Endotoxin

概要

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Difference between carbon particles and bacterial endotoxin in their modes of radioprotection was examined. Radioprotection by bacterial endotoxin was carried out without corresponding enhancement of the haemopoietlc stem cell survival, whereas the increased survival of the carbon treated anlmals was in good accordance with the enhancement of the survival of the haemopoletic stem cells in the treated animals. Radioprotection by bacterial endotoxin, therefore, seems to be due to the enhanced induction of the differentiation of the stem cells to recruit functloning blood cells. Survival of sublethally irradiated animals depends mainly on the recovery of haemopoietic function. Restoration of such haemopoietic cells can be greatly enhanced by the administration to animals of particulate substance such as carbon particles or bacterial endotoxin. The former has been shown to blockade reticuloendothelial system (RES), which as a result gives a favourable environment for the recovery of haemopoietic stem cells, whereas the latter is known to simulate RES and enhance the immune response.
日本放射線影響学会の論文