Life-threatening Hyperkalemia during a Combined Therapy with the Angiotensin Receptor Blocker Candesartan and Spironolactone
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概要
- 論文の詳細を見る
We describe a hypertensive nephrosclerosis patient presenting with severehyperkalemia due to a combination therapy of the angiotensin receptor blocker (ARB)candesartan and spironolactone despite mildly decreased renal function. Recently,ARBs are replacing the ACE inhibitors. The combined therapy with ARB andspironolactone will eventually become the standard regimen. The strict attention andclose monitoring of serum potassium should be mandatory in combination therapy toprevent hyperkalemia. Assessment of trans-tubular potassium gradient (TTKG) andfractional excretion of potassium (FEK) before starting the therapy would help inidentifying the patients at higher risk of developing hyperkalemia. Co-administrationof thiazide or loop diuretics is recommended to reduce the risk of hyperkalemia.
- 神戸大学の論文
著者
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KAWANO Yuhei
National Cardiovascular Center
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Yoshihara Fumiki
Division Of Hypertension And Nephrology National Cardiovascular Center
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Fujioka Yoshihiko
国立循環器病センター
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Yoshihara Fumiki
国立循環器病センター 高血圧腎臓内科
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Nakahama Hajime
Division Of Hypertension And Nephrology National Cardiovascular Center
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Fujii Hiroko
Division Of Hypertension And Nephrology
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Ienaga Takashi
National Cardiovascular Center
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Fujii Hideki
Division Of Nephrology And Dialysis Center Kobe University Graduate School
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Yoshihara Fumiki
National Cardiovascular Center Research Institute
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Fujii Hideki
National Cardiovascular Center
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Nakahama Hajime
National Cardiovascular Center
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Nakamura Satoko
National Cardiovascular Center
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Fujii Hiroko
神戸大学 腎臓内科学
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