非晶質リン酸カルシウムからの水酸アパタイト硬化体作製

概要

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The most suitable condition to prepare a hardened hydroxyapatite(Ca_<10>(PO_4)_6(OH)_2, HAp)body from amorphous calcium phosphate(Ca_3(PO_4)_2・nH_2O, ACP)was investigated to develop a biomaterial for the repair of bony defects. The hardened HAp bodies were prepared by mixing dicalcium phosphate dihydrate(CaHPO_4・2H_2O, DCPD), various carboxylic acid solutions and amorphous tricalcium phosphate(ATCP)obtained by heating ACP at 500℃. The properties of the hardened HAp bodies were characterized by measuring compressive strength and X-ray diffraction. The compressive strength of the hardened bodies depended on the amount of DCPD, types of carboxylic acids, concentrations of carboxylic acid solutions, water/solid weight ratios, aging time and temperature. Particularly, the type of carboxylic acid considerably influenced the compressive strength. For example, utilization of glycine as a carboxylic acid showed a value of 5.5 MPa in compressive strength at maximum although that of maric acid showed a value of only 3.0 MPa. The values of compressive strength were positively correlated to the first dissociation constant. Glycine was found to be effective to increase the compressive strength of the hardened bodies.
社団法人日本セラミックス協会の論文
1998-10-01