アパタイト型希土類含有化合物の合成と生体親和性の評価

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Synthesis and applicability for biomedical use of barium rare earth oxide silicates were studied. Barium rare earth oxide silicates (Ba_<2+x>Ln_<8-x>(SiO_4)_6O_<2-x/s>; Ln=La, Ce, Pr, Nd, Sm, Eu, Gd, Dy) were synthesized by solid state reaction at 1400℃ in air for 2 h. Except for Ln=Ce, Dy, the synthesized powders were identified single phase of barium rare earth oxide silicates (Ba_2Ln_8(SiO_4)_6O_2) by XRD. The samples were including OH^- and Co_3^<2-> in O^<2-> site of the lattice by IR analysis. The powders with Ba_4La_6(SiO_4)_6O type (x=2) compositions were sintered at 1400℃ in air for 2 h, and the maximum relative density was 96%. Biocompatibility of the barium rare earth oxide silicate ceramics was estimated by in vitro and in vivo tests. Osteoblast-like (MC3T3-E1) and fibroblast (L929) cells were cultured on the obtained ceramics. After cultivation, cell proliferation and many gap junctions between the cells were observed on all the barium rare earth oxide silicate ceramics. It was confirmed that barium rare earth oxide silicates had an affinity to cultured cells. Ba_4Eu_6(SiO_4)_6O is the most biocompatible material for cell proliferation and adhesion in the obtained ceramics, and the compatibility was equal to that of HAp ceramics. The sintered Ba_4Eu_6(SiO_4)_6O was implanted under the skin of Wister rats for 7 d. The tissue reaction, observed in the hematoxylin-eosin stained section, indicated that barium europium oxide silicates had a good biocompatibility.
社団法人日本セラミックス協会の論文
2001-02-01

アパタイト型希土類含有化合物の合成と生体親和性の評価

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