Reduction of Superoxide Dismutase Activity Correlates with Visualization of Edema by T_2-weighted MR Imaging in Focal Ischemic Rat Brain

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概要

• 論文の詳細を見る

• This study investigated the correlation between in vivo serial T_2-weighted magnetic resonance (MR) imaging and changes in superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) activities, and water, sodium ion (Na^+), and potassium ion (K^+) contents measured in vitro using rat brain following right middle cerebral artery occlusion in conjunction with bilateral common carotid artery (CCA) occlusion. One hour later the left CCA was released. Serial MR images showed edema developed from the outer cortex towards the center. The T_2 signal intensity of the injured right cortex increased with time compared to that of the contralateral cortex. Increased Na^+ and water and decreased K^+ contents occurred in the injured cortex, indicating that serial T_2-weighted MR imaging reflects the changes in water content and Na^+ and K^+ concentrations determined by biochemical techniques. GSH-Px activity was little changed. Total SOD in the injured cortex decreased 1 hour after ischemia and remained low throughout the experiment. In contrast, SOD activity in the noninfarcted left cortex also decreased after 1 hour but returned to normal after 2 hours of ischemia. Our results suggest that oxygen free radicals are important in developing ischemic brain edema and cerebral infarction.

• 日本脳神経外科学会の論文
• 1994-01-15

著者

• YOSHIMOTO Takashi

  Department of Legal Medicine, Nagoya University School of Medicine

• Yoshimoto Takashi

  Department Of Chemical Engineering Graduate School Of Engineering Kyushu University

• Imaizumi Shigeki

  Cns Injury And Edema Research Center Department Of University Of California:m.d. Department Of Neuro

• Chan Pak

  Cns Injury And Edema Research Center Department Of University Of California

• CHANG Lee

  Department of Pharmaceutical Chemistry and Radiology, University of California

• COHEN Yoram

  Department of Pharmaceutical Chemistry and Radiology, University of California

• WEINSTEIN Philip

  Department of Neurological Surgery, University of California

• JAMES Tom

  Department of Pharmaceutical Chemistry and Radiology, University of California

• Weinstein Philip

  Department Of Neurological Surgery University Of California

• Weinstein Philip

  Department Of Dental Public Health Sciences University Of Washington

• James Tom

  Department Of Pharmaceutical Chemistry And Radiology University Of California

• Cohen Yoram

  Department Of Pharmaceutical Chemistry And Radiology University Of California

• Chang Lee

  Department Of Pharmaceutical Chemistry And Radiology University Of California

• Yoshimoto Takashi

  Department Of Neurological Surgery Tohoku University School Of Medicine

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