Brain pH Responses to Acetazolamide and Hypercapnia in Cats
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概要
- 論文の詳細を見る
The involvement of increased brain tissue CO_2 tension in acetazolamide-induced brain acidosis was investigated by compating the brain pH response to acetazolamide with that to hypercapnia. CO_2 and pH sensors were placed bilaterally into cerebral white matter to 15 mm depth in cats. Group 1 cats (n = 9) breathed spontaneously, and in situ brain tissue P_ltco_2gt and pH (Pb_ltco_2gt and pHb) were measured after intravenous acetazolamide administration (20 mg/kg). Group 2 cats (n = 9) were paralyzed and ventilated mechanically, and the changes of pHb were investigated by adjusting the ventilation to maintain the same Pb_ltco_2gt values as in the acetazolamide-treated group. Pb_ltco_2gt changes were not significantly different between the two groups. However, pHb responses were quite different: the fall in pHb was progressive in Group 1 but transient in Group 2. Brain acidosis after acetazolamide administration is not due to the rise in brain tissue CO_2 tension.
- 日本脳神経外科学会の論文
- 1997-04-15
著者
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Kohshi Kiyotaka
Department Of Neurosurgery University Of Occupational And Environmental Health
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Kohshi Kiyotaka
Department Of Hyperbaric Medicine:department Of Neurosurgery School Of Medicine University Of Occupa
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Kohshi Kiyotaka
Departments Of Neurosurgery And Hyperbaric Medicine School Of Medicine University Of Occupational An
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KINOSHITA Yoshimasa
Department of Neurosurgery, University of Occupational and Environmental Health
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FUKATA Koichi
Division of Glinical Examination, School of Medical Technology, University of Occupational and Envir
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Fukata Koichi
Division Of Glinical Examination School Of Medical Technology University Of Occupational And Environ
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Kinoshita Yoshimasa
Department Of Hyperbaric Medicine School Of Medicine University Of Occupational And Environmental He
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合志 清隆
Departments of Neurosurgery and Hyperbaric Medicine, School of Medicine, University of Occupational and Environmental Health
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