EFFECT OF LH-RH ON LH RELEASE FROM THE DISPERSED PITUITARY CELLS OF PREGNANT RATS
スポンサーリンク
概要
- 論文の詳細を見る
In order to study the mechanism which induces a sudden drop in serum LH Levels between day 11 and 13 of pregnancy in rats, LH responses of the pituitary to LH RH were investigated using an in vitro incubation system of the dispersed pituitary cells. Dispersed pituitary cells, obtained on day 10 or 15 of pregnancy, were incubated for 3 hours with synthetic LH RH. The addition of 5ng LH RH significantly increased the release of LH from the pituitary cells both on days lo and 15 of pregnancy. The response of LH to LH RH was significantly greater on day 10 than 15. A combination treatment of estradiol and progesterone blocked the stimulatory effect of LH RH on LH release on day 10 but not on day 15. These results indicated that LH responsiveness of the pituitary was decreased between day 10 and day 15 of pregnancy, and this would play an important role in the lowering of serum LH Levels during mid pregnancy in rats. A possible role of progesterone and estradiol in the regulation of the responsiveness of the pituitary to LH RH was also suggested
- 社団法人日本産科婦人科学会の論文
- 1984-01-01
著者
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Ueda Kazuyuki
Department Of Applied Physics Faculty Of Engineering Osaka University
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Ueda Kazuyuki
Department Of Obstetrics And Gynecology. Yamaguchi University School Of Medicine
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