長期におよぶ子宮内膜症管理中に発生した卵巣明細胞腺癌の1例 : ダナゾール投与中のCA125の推移について

概要

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A 36-year-old patient with clear cell adenocarcinoma stage IIIc developing within ovarian endometriosis was reported. She presented at our clinic with sterility and was diagnosed with ovarian endometriosis. She was treated with Danazol and the levels of CA 125 fell during the first and the second treatments to those found in a normal controls, but a significant reduction was not seen during the third treatment. A solid part was detected by ultrasonograpy because cancer was supected two years after the third Danazol therapy. Optimal surgery was performed and pathological examination revealed clear cell adenocarcinoma. She was subsequently treated with chemotherapy, but she showed evidence of bone metastasis and died 38 months after the initial diagnosis. CA 125 may be a reliable indicator of cancer daveloping within endometriosis for monitoring the efficacy of Danazol treatment for endometriosis.
社団法人日本産科婦人科学会の論文
2000-10-01