母体血清中Pregnancy Associated Plasma Protein A (PAPP-A)の動態に関する研究

概要

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Recently an immunoradiometric assay (IRMA) for pregnancy associated plasma protein A (PAPP-A) has been developed by Ortho-Clinical Diagnostic. In this study we confirmed that this IRMA for PAPP-A is very sensitive, specific and reproducible. Serum levels of PAPP-A during gestation in normal pregnancy continued to rise until term and reached 831±386mg/l at 39 weeks of gestation. In the case of incomplete abortion, missed abortion and ectopic pregnancy, maternal serum PAPP-A levels were significantly lower than in normal pregnancy, but we could not find significant differences between maternal serum PAPP-A levels in 7 cases of Down's syndrome and normal pregnancy. It is suggested that we should discuss the usefulness of PAPP-A as a marker for the detection of abnormal pregnancy in a greater number of cases, and it would appear that combination assay for PAPP-A with other pregnancy-associated proteins such as hCG and hPL etc. might be more effective for screening for abnormal pregnancy.
社団法人日本産科婦人科学会の論文
1999-12-01