発達過程における腸管のコリン作動機構の生化学的研究

概要

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For the purpose of recognizing the functional development of intestinal motility during foetal life, the change of cholinergic activity was studied biochemically in rabbit foetuses. The esophagus, stomach, small intestine and colon were removed from rabbit foetuses in 3 or 4 days' interval, for measuring the ChAT and AchE activities. The ChAT activity of small intestine was significantly higher in the 28th day comparing with those of the 18th and 21st day. The activity of ChAT and AchE of esophagus, stomach and colon were not significantly increased during foetal development. In comparison of the activity of ChAT and AchE for the location of alimentary tract, the activities of ChAT and AchE were higher in colon than any other location. There was positive correlation between the ChAT and AchE activity. The similarity in the developmental pattern between ChAT and AchE activity suggests the co-existence of Acethylcholine itself in those foetal intestines.
日本小児外科学会の論文