SEASONAL INCIDENCE OF SUBCLINICAL VITAMIN K DEFICIENCY DURING EARLY NEWBORN PERIOD
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概要
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特発性乳児ビタミンK欠乏症は生後1カ月頃に好発し, 母乳栄養以外に原因が特定できない予後不良の疾患である. 過去における全国調査で, 夏から初秋に多発する傾向が認められているが, その理由は不明である. ビタミンK欠乏症の診断にPIVKA-IIが用いられ, なんらの出血症状も認めない潜在性ビタミンK欠乏症の存在が明らかになった. われわれは早期新生児期における潜在性ビタミンK欠乏症に特発性乳児ビタミンK欠乏症で認められた季節偏在性が存在するかどうか調査する目的で, 2年間にわたり1,166人の新生児をPIVKA-IIとヘパプラスチンテストの両方を用いてスクリーニングした. 1,070人(91.8%)の新生児は, PIVKA-IIが陰性であったが, 96人(8.2%)は1μg/ml以上の陽性であった. 96人の陽性群をさらに低値群と高値群に分けると13人(1.1%)が2〜8μg/mlの高値群に属し, これら13人のうち11人が夏から初秋(6〜9月)に有意に集中していた(p<0.05). PIVKA-IIの陰性群と陽性群, また陽性群の中の低値群と高値群はそれぞれヘパプラスチンテストの平均値に有意差を認めた. 早期新生児期での重症型潜在性ビタミンK欠乏症が夏から初秋に多いという季節偏在性は特発性乳児ビタミンK欠乏症の疫学調査と一致し, 二つのビタミンK欠乏症の原因における関連性が推察された.
- 社団法人日本産科婦人科学会の論文
- 1991-03-01
著者
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穴井 孝信
Department Of Obstetrics And Gynecology Medical College Of Oita
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YOSHIMATSU Jun
Department of Obstetrics and Gynecology, Oita Medical University
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MIYAKAWA Isao
Department of Obstetrics and Gynecology, Oita Medical University
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OGA Masayuki
Department of Obstetrics and Gynecology, Saga Medical School
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Oga Masayuki
Department Of Obstetrics And Gynecology Medical College Of Oita
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Yoshimatsu Jun
Department Of Obstetrics & Gynecology Oita Medical University
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Yoshimatsu Jun
Department Of Obstetrics And Gynecology Medical College Of Oita
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MATSU Takafumi
Department of Obstetrics and Gynecology, Medical College of Oita
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Miyakawa Isao
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
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Miyakawa Isao
Department Of Obstetrics And Gynecology Medical College Of Oita
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Matsu Takafumi
Department Of Anesthesiology Miyazaki Medical College
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Matsu Takafumi
Department Of Obstetrics And Gynecology Medical College Of Oita
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