PIVKA-II (PROTEIN INDUCED BY VITAMIN K ABSENCE-II) STATUS IN NEWBORNS EXPOSED TO ANTICONVULSANT DRUGS IN UTERO
スポンサーリンク
概要
- 論文の詳細を見る
抗てんかん剤服用妊婦から出生した新生児は生後24時間以内に重篤なビタミンK欠乏症に陥る危険性があることが知られている. 抗てんかん剤服用妊婦から出生した5人の新生児をPIVKA-IIとへパプラスチンテストで検査し, コントロール群と比較した. 方法:5生日に足踵部より3.1%クエン酸加血での採血で同時にPIVKA-IIとヘパプラスチンテストを測定した. PIVKA-IIはラテックス凝集法を用いて測定し, カットオフ値を1μg/mlとした. 成績:抗てんかん剤服用妊婦から出生した5人の新生児はいずれもPIVKA-IIが1μg/ml以上の値を示して陽性であったが, コントロール群の陽性率は8.2%(96/1,166)に留まり, 有意差(p<0.005)を認めた. 他方, ヘパプラスチンテストでは服用群は46.0±8.5%とコントロール群の50.9±10.3%に比較して低い値を示したが, 有意差は認められなかった. しかし, 服用群が完全人工栄養に対し, コントロール群がほぼ完全な母乳栄養であったことを考慮すればより大きな差が存在すると考えられた. 結論:抗てんかん剤服用妊婦から出生した新生児は少なくとも生後数日間はビタミンK欠乏症に陥る危険性を有する. フェノバルビタールやアレビアチンのみならず, 他の抗てんかん剤についても留意する必要がある.
- 社団法人日本産科婦人科学会の論文
- 1991-03-01
著者
-
穴井 孝信
Department Of Obstetrics And Gynecology Medical College Of Oita
-
YOSHIMATSU Jun
Department of Obstetrics and Gynecology, Oita Medical University
-
MIYAKAWA Isao
Department of Obstetrics and Gynecology, Oita Medical University
-
OGA Masayuki
Department of Obstetrics and Gynecology, Saga Medical School
-
Oga Masayuki
Department Of Obstetrics And Gynecology Medical College Of Oita
-
Yoshimatsu Jun
Department Of Obstetrics & Gynecology Oita Medical University
-
HIROTA Yoshiko
Department of Obstetrics and Gynecology, Medical College of Oita
-
Miyakawa Isao
Department Of Applied Biological Chemistry Faculty Of Agriculture Tohoku University
-
Hirota Yoshiko
Department Of Obstetrics And Gynecology Medical College Of Oita
関連論文
- Intraplacental choriocarcinoma with fetomaternal transfusion
- QUANTITATIVE DESCRIPTION OF SUBJECTIVE SYMPTOMS IN PREGNANT WOMEN AND THEIR CHANGES DURING THE PERINATAL PERIOD
- Synthesis of 4'-C-Methylnucleosides
- IS-95 Fourier transform infrared analyses of erythrocyte peroxidation in preeclampsia
- PIVKA-II (PROTEIN INDUCED BY VITAMIN K ABSENCE-II) STATUS IN NEWBORNS EXPOSED TO ANTICONVULSANT DRUGS IN UTERO
- SEASONAL INCIDENCE OF SUBCLINICAL VITAMIN K DEFICIENCY DURING EARLY NEWBORN PERIOD
- P3-IS-63 Three-dimensional sonographic findings in congenital ichthyosis(Group92 Reproduction2,International Session)
- P3-IS-51 Three-dimensional volume sonography for nuchal translucency thickness measurements : second report(Group90 Perinatology+Women's Health2,International Session)
- P-IS-86 A clinical utility of three-dimensional extended imaging : a new 3D image processing technology(Perinatology 4,Group 109,International Session)
- Soluble fms-like tyrosine kinase 1 (sFlt-1) production in villous trophoblast with hypoxic stimulation(Perinatology 4)
- Soluble fms-like tyrosine kinase 1 (sFlt-1), free VEGF and PlGF in normal pregnancy and preeclampsia(Perinatology 4)
- 15-28.Regulation of metallothionein expression in amniotic cells (Session 17 Perinatology 6)
- Genome-scale analyses of differential gene expression in preterm pups(Session19 Peninatology4)
- IS-33 SMOKING AND IUGR : EFFECT OF A CIGARETTE SMOKE EXTRACT ON THE PAFMETABOLISM BY DECIDUAL MACROPHAGES
- IS-143 Proliferation of Smooth Muscle Cells of Umbilical Vessels in Fetal Growth Restriction
- Absence of Vagina and Hypoplasia of the Urethra and Ectopia of the Ureter
- Adenoid cystic carcinoma of the uterine cervix
- The analysis of intracellular signal transduction system with vascular endothelial growth factor production in amniotic cells(Perinatology 1)
- Angiogenic effect of human follicular fluids(Reproduction 4)
- Cultured human endometrial epithelial cells produce thymus and activation-regulated chemokine upon stimulation with interleukin-4 and interleukin-13(Reproduction 2)
- 15-23.Effect of Interferon-γ on the Secretion of Platelet-activating Factor Acetylhydrolase by Human Decidual Macrophages. (Session 16 Perinatology 5)
- 8-21.The production of macrophage colony-stimulating factor and macrophage chemoattractant protein-1 by human granulosa cells(Session 11 Reproduction 4)
- 8-20.The production of macrophage inflammatory protein-3α in human follicular fluids and cultured granulosa cells(Session 11 Reproduction 4)
- Activation of protein kinase C inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages
- IS-44 Suggested modulators of GRO-α expression by a granulosa cell line
- IS-43 Possible modifiers of IL-8 expression by a granulosa cell line
- IS-37 Effect of Epidermal Growth Factor on the Production of Vascular Endothelial Growth Factor by Endometrial Stromal Cells
- IS-36 Effects of Th1 and Th2 Cytokines on the Secretion of Platelet-activating Factor Acetylhydrolase by Human Decidual Macrophages
- Immunohistochemical Study of c-erb B-2 Expression in Malignant Mixed Mullerian Tumors of the Female Genital Tract
- Effects of Sex-steroids on the Secretion of Platelet-activating Factor Acetylhydrolase by Human Decidual Macrophages.(Session18 Reproduction4)
- Possible role for TGF-a and EGF in the inflammatory mechanism of human ovulation(Session17 Reproduction3)
- The production of vascular endothelial growth factor and hepatocyte growth factor in human follicular fluid(Session17 Reproduction3)
- IS-50 Effects of Gluco-and Mineralo-corticoids on the Secretion of Platelet-activating Factor Acetylhydrolase by Human Decidual Macrophages
- Pregnancy complicated with lactate dehydrogenase M-subunit deficiency : The first case report
- Homologous carcinosarcoma of the uterine corpus associated with tamoxifen therapy
- A rare case of bilateral small cell carcinoma of the ovary diagnosed during pregnancy
- Remission of Idiopathic Hypoparathyroidism during Lactation : A Case Report
- Pregnancy-Associated Osteoporosis with Elevated Levels of Circulating Parathyroid Hormone-Related Protein : A Report of Two Cases
- A Case of Primary Non-Hodgkin's Lymphoma of the Uterine Cervix Treated by Combination Chemotherapy (THP-COP)
- Magnetic Resonance Imaging of Fetal Autosomal Recessive Polycystic Kidney Disease
- S-48 Hormonal regulation and mRNA expression of platelet-activating factor acetylhydrolase in HL-60 cells
- Usefulness of Plasma Kisspeptin Levels as a Biomarker in the Diagnosis of Perinatal Complication
- Unconjugated Estradiol, Estriol and Total Estriol in Maternal Peripheral Vein, Cord Vein, and Cord Artery Serum at Delivery in Pregnancies with Intrauterine Growth Retardation
- Maternal Outcome in Pregnancy Complicated With Pulmonary Arterial Hypertension
- Markedly reduced ventricular arrhythmia during the peripartum period in a pregnant woman with Andersen-Tawil syndrome
- Subarachnoid Hemorrhage From Intracranial Aneurysms During Pregnancy and the Puerperium
- Safety and Efficacy of Implantable CardioverterDefibrillator During Pregnancy and After Delivery
- Safety and Efficacy of Implantable Cardioverter-Defibrillator During Pregnancy and After Delivery
- Cardiovascular Events in Pregnancy With Hypertrophic Cardiomyopathy
- Subarachnoid Hemorrhage From Intracranial Aneurysms During Pregnancy and the Puerperium