先天性サイトメガロウイルス感染症の3例 : 胎児治療の試み

概要

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Three cases of congenital Cytomegalovirus (CMV) infection were perinatally managed in Hokkaido University Hospital. In case 1, prenatal CT and MRI revealed dilation of ventlicles and calcification in the peliventriculararea. A male infant weighing 3,020g was born at 39 weeks of gestation (GW). He is 9 years old and has a severe hearing problem. In case 2, by prenatal ultrasound examinations, IUGR, dilation of ventricles, and hepatosplenomegaly were detected. A male infant weighing 1,800g was born at 38 GW, and died at 5 months after birth. Fetal ascites was first detected at 25 GW in case 3. Immunoglobulin (2.5g) was directly infused in to the fetal peritoneal cavity at 28 and 29 GW. At 34 GW, a male infant weighing 2,340g was born by cesarean section due to fetal distress. CMV DNA detected by PCR turned negative in neonatal ascites. He is 1 year old and has noneurological abnormality. Direct fetal infusion of immunoglobulin may be beneficial in treating congenital CMV infection.
社団法人日本産科婦人科学会の論文
1999-03-01