HTLV-I母子感染をモデルとした胎盤バリア機構へのウイルス感染胎盤絨毛細胞のアポトーシスの関与に関する研究(シンポジウム2 母子感染の診断と対応)

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The placenta serves as a barrier against mother-to-fetus transmission of many microorganisms. The mechanism of this barrier system of the placenta has not well studied. Recently, apoptosis, which is another type of cell death and is very different from necrosis, has been paid much attention by researchers in both basic and clinical medicine, because it is involved in organogenesis, autoimmune diseases, cancers and viral infectious diseases. In the present study, in order to examine whether or not apoptosis is involved in the barrier system of the placenta against mother-to-fetus transmission of HTLV-I, infection by HTLV-I was tested by immunostaining, and apoptosis was tested by TdT-mediated dUTP nick end labeling (TUNEL) method. Eight of 16 placentas from HTLV-I carrier mothers were infected with HTLV-I, but none of the 16 relevant cord blood samples was infected, whidh suggested the barrier system of the placenta against mother-to-fetus transmission of HTLV-I. The number of apoptosis-positive cells in the placentas from the HTLV-I carrier mothers were higher than non-carrier mothers. In an in vitro experiment of co-culturing placental cells with MT-2 cells (HTLV-I-infected lymphocyte cell line), the number of apoptosis-positive placental villous cells was higher than the culture without MT-2 cells. The number of apoptosis-positive MT-2 cells was increased in the co-clture with placental cells compared with the culture of MT-2 cells alone. It is concluded that apoptosis is involved in the barrier system of the placenta against mother-to-fetus transmission of HTLV-I.
社団法人日本産科婦人科学会の論文
1998-08-01

HTLV-I母子感染をモデルとした胎盤バリア機構へのウイルス感染胎盤絨毛細胞のアポトーシスの関与に関する研究(シンポジウム2 母子感染の診断と対応)

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