心弁信号,ドプラ血流波形および血管壁微小変異からみたヒト胎児における心機能の発達ならびに病的逸脱に関する研究(<特集>第56回学術講演会シンポジウム1 : 胎児の発育・分化とその異常)

概要

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Investigated was the clinical significance of the measurement of both the cardiac isovolumetric contraction time (ICT) and the pulse waveforms in the descending aorta in the human fetus. ICTs obtained from human fetuses with elevated PI values in the umbilical artery demonstrated the significant relationship between the prolongation of ICT and the abnormal fetal outcome. On the other hand, both the amplitude and the amplitude/end-diastolic diameter ratio (Amp/EDD) in the pulse waveforms in the descending aorta demonstrated the significant decrease in cases with fetal cardiac dysfunction and/or elevated placental vascular resistance. In the fetal lamb experiments, ICT had the significant negative and positive relationship with Max dP/dt value in the left ventricle and the arterial pH, respectively, and both the amplitude and Amp/EDD in the descending aorta had the significant positive relationship with the aortic pulse amplitude and PaO_2. These results indicate that the fetal ICT and the pulse waveforms might be sensitive and noninvasive parameters for evaluating the cardiac contractility influenced by pH and the aortic pressure amplitude influenced by PaO_2.
社団法人日本産科婦人科学会の論文
2004-09-01