激運動に対する熱ショック応答に及ぼす運動トレーニングの効果

概要

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This study was conducted to examine the effect of exercise training on heat-shock response, the protective response to heat, oxidative stress and other stresses characterized by elevated synthesis of heat-shock proteins(HSP), in strenuous exercise. Five untrained men(aged 20-21)participated in the study. The protocol included strenuous exercise to exhaustion by bicycle ergometer(1 st Ex), 4 weeks of training(a 2 km run three days per week)and a repetition of the strenuous exercise(2 nd Ex). We measured VO_2 and VCO_2 with a respiratorygas analyzer, 70 kDa heat-shock protein(HSP 70)of mononuclear cells by western blotting, and rectal and mean skin temperatures by thermistors during the strenuous exercise. After 4 weeks of training, VO_2max was increased significantly(p<0.05). HSP 70 increased immediately after the exercise in 3 of 5 subjects in the 1 st Ex, but not in the 2 nd Ex. Rectal temperatures rose significantly after both the 1 st and 2 nd Ex(p<0.05). Mean skin temperatures fell significantly after both the 1 st and 2 nd Ex(p<0.05). There was no correlation between rectal and mean skin temperatures and HSP 70. We observed the heat-shock response during strenuous exercise and the attenuation of this response after 4 weeks of exercise training. These results suggest that exercise training may have suppressive effects on the heat-shock response during strenuous exercise.
日本体力医学会の論文
1994-10-01