ステロイド軟膏からの主薬の放出性(I) : ホウ酸亜鉛華軟膏との混合軟膏の安定性と放出性

概要

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The stabilities and the release of hydrocortisone-17-butyrate (HC-17-B), fluocinonide (FLC), amcinonide (AMC), beclomethasone dipropionate (BCM-DP), triamcinolone acetonide (TCA), betamethasone dipropionate (BM-DP) and betamethasone valerate (BM-V) in admixtures of commercial ointment with boric acid and zinc oxide ointment (BZO) were studied. Determination of several corticosteroids were made by high-performance liquid chromatography. The stabilities were recorded immediately after admixing and after storage for 2,4,8 and 12 weeks at 5℃,25℃ and 40℃. FLC, AMC, BCM-DP and BM-DP were stable in all cases, but after storage for 12 weeks at 40℃, 88.4% of BM-V, 88.6% of TCA and 31.2% of HC-17-B remained in the admixtures. The amounts of all corticosteroids released from commercial ointments admixed with BZO were greater than those from the individual commercial ointments.
日本医療薬学会の論文
1987-06-20