ステロイド軟膏からの主薬の放出性(II) : 放出性におよぼす他剤との混合の影響

概要

論文の詳細を見る
The effect of mixing with other ointment and the ratio of admixture on in vitro release of betamethasone dipropionate (BM-DP) from 4 different model ointment bases were investigated. The bases used included white petrolatum (WP)-purified lanoline bases (I), WP-liquid paraffin bases (II), WP-propylene glycol bases (III) and plastibase (PB) bases (IV). Ointment used for admixture was zinc oxide (10%) ointment (ZO) alone and ointment bases I through IV above. The ratios of admixture were adjusted so that the final concentrations of the mixed ointment were 0,1/4, 2/4 and 3/4. The release of BM-DP from the bases was measured by HPLC. As the amount of BM-DP released fitted Higuchi's equation, the release rate constant (K) was calculated by that equation. Constant K of BM-DP from the model ointments mixed with WP bases (I through III) and PB bases (IV) decreased in proportion to the decrease in BM-DP levels, but when the concentration of ZO added was 1/4 or 2/4, the constant K reached the maximum and gradually decreased thereafter, as it was intended for clinical efficacy. From the above, it was suggested that this could be a simple but useful method for determination of compatibility and selection of the proper ratios of mixture of corticosteroid ointment with other bases or ointments.
日本医療薬学会の論文
1987-06-20