EFFECT OF ADMINISTRATION ROUTES OF MONOSODIUM GLUTAMATE ON PLASMA GLUTAMATE LEVELS IN INFANT, WEANLING AND ADULT MICE

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The time course of concentrations of glutamate in plasma was examined following a single dose of 1 g/kg body weight of monosodium glutamate (MSG) by intraperitoneal or subcutaneous injection or peroral intubation in 10-day, 23-day and 4-month-old mice of ICR strain. Ad libitum dietary administration in shorter period of time and effects of food accompaniment were also investigated. Levels of plasma glutamate rapidly elevated and reached maximum from 10 to 30 minutes after administration of an aqueous solution of MSG and then returned to normal levels by 90 minutes. Peak values in peroral intubation were significantly lower than those in intraperitoneal or subcutaneous injection, especially in infants and weanlings. Food accompaniment markedly suppressed elevations of plasma glutamate. In dietary administration, maximum levels of plasma glutamate, which were remarkably low as compared with those in food accompaniment, never exceeded 5-fold of base-line values.
1977-07-15