2-メルカプトベンゾチアゾ-ルのコイ体内における吸収,分布および排泄〔英文〕

概要

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The absorption, tissue distribution, and excretion of 2-mercaptobenzothiazole (M) were investigated using 14C-M. When a carp was starved after administration of 14C-M, after 1-h the radioactivity which remained in the intestine was 45% of the dose, and after 72-h the activity in the bile was about 9% and in the other tissues was less than 0.05% of the dose. This radioactive chemical in the bile was determined to be benzothiazole-2-mercaptoglucuronide. On the other hand, when a carp was fed after administration of 14C-M, after 72-h the radioactivity in the bile was less than 0.3% and in the other tissues was negligible in amount. Thus, about 100% of the dose was excreted into the water.